The severity of salmonella infections depends in part on how effectively the invaders are destroyed. Incisive experiments now show that host defence in the intestine centres on the aptly named defensins.
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References
Lehrer, R. I., Lichtenstein, A. K. & Ganz, T. Annu. Rev. Immunol. 11, 105–128 (1993).
Lehrer, R. I. & Ganz, T. Curr. Opin. Immunol. 14, 96–102 (2002).
Bulet, P., Hetru, C., Dimarcq, J. L. & Hoffmann, D. Dev. Comp. Immunol. 23, 329–344 (1999).
Thomma, B. P., Cammue, B. P. & Thevissen, K. Planta 216, 193–202 (2002).
Salzman, N. H., Ghosh, D., Huttner, K. M., Paterson, Y. & Bevins, C. L. Nature 422, 522–526 (2003).
Zhang, S. et al. Infect. Immunol. 71, 1–12 (2003).
Ayabe, T. et al. Nature Immunol. 1, 113–118 (2000).
Wilson, C. L. et al. Science 286, 113–117 (1999).
Nizet, V. et al. Nature 414, 454–457 (2001).
Qu, X. D., Lloyd, K. C., Walsh, J. H. & Lehrer, R. I. Infect. Immunol. 64, 5161–5165 (1996).
Ganz, T. J. Clin. Invest. 109, 693–697 (2002).
Metchnikoff, E. Immunity in Infective Diseases (Cambridge Univ. Press, 1905).
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Ganz, T. Gut defence. Nature 422, 478–479 (2003). https://doi.org/10.1038/422478a
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DOI: https://doi.org/10.1038/422478a