Table of contents


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Editorial

How to slake a planet's thirst p243

Our growing demand for water threatens the world's development and security. Solving this crisis need not involve flashy technologies. But it will require science, plus a large dose of political will.

doi:10.1038/422243a


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News

Biodefence plans earn lukewarm response from US academics p245

Erika Check

doi:10.1038/422245a


Biotech firms join charities in drive to help Africa's farms p246

Hannah Hoag

doi:10.1038/422246a


Health labs focus on mystery pneumonia p247

David Cyranoski


Chicken flu races through Dutch poultry farms p247

Alison Abbott

doi:10.1038/422247b


Revamped accelerator seeks quark's secrets p248

Geoff Brumfiel

doi:10.1038/422248a


NATO reform promises more publicity for less science p248

Quirin Schiermeier

doi:10.1038/422248b


NASA intensifies probe into Columbia failure p249

Tony Reichhardt


Alien-hunters get scope to search p249

John Whitfield

doi:10.1038/422249b


news in brief p250

doi:10.1038/422250a


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news feature

The world's forgotten crisis p251

Over a billion people cannot get clean water, and things are getting worse.

Peter Aldhous


Atlas of a thirsty planet p252

doi:10.1038/422252a


Delta blues p254

Living on the flood plain of three great rivers, the people of Bangladesh endure floods, drought, water-borne disease and much else besides. Can they entertain any hope of relief? Tom Clarke investigates.

Tom Clarke


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Correspondence

Venezuela: the other side of the story p257

No political campaigning in public institutions, but free speech is manifest in e-mail debate.

M. García Sucre, L. Marcano, R. Padrón, J. Acosta and L. Burguillos

doi:10.1038/422257a


Venezuela: crisis puts major institutions at risk p257

Jaime Requena

doi:10.1038/422257b


If atomic precision is unfeasible, so is life p257

K. Eric Drexler

doi:10.1038/422257c


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Commentary

The politics of publication p259

Authors, reviewers and editors must act to protect the quality of research.

doi:10.1038/422259a


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Book Reviews

Counting the cost p263

Can cost–benefit analysis solve the problem of assessing environmental risk?

Raymond T. Pierrehumbert reviews Risk and Reason: Safety, Law, and the Environment by Cass R. Sunstein

doi:10.1038/422263a


The smart bird of the south p264

Yvon Le Maho and David Grémillet review The Adélie Penguin: Bellwether of Climate Change by David G. Ainley

doi:10.1038/422264a


A relative view of the Universe p264

doi:10.1038/422264b


Networks untangled p265

Lada Adamic reviews Six Degrees: The Science of a Connected Age by Duncan J. Watts

doi:10.1038/422265a


New in paperback p265

doi:10.1038/422265b


Correction p265

doi:10.1038/422265c


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Lifeline

A comic-book hero: Kazuhiko Kinosita Jr p266

doi:10.1038/422266a


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News and Views

Cell biology: Just mix and patch p267

A single layer of epithelial cells makes up the primary barrier to infection in our bodies. This layer is poised to repair damage quickly, patching up any holes to keep invading organisms out.

Keith Mostov and Mirjam Zegers

doi:10.1038/422267a


Astronomy: Glowing embers p268

The combined efforts of telescopes around the world have tracked the development of the 'afterglow' that follows a gamma-ray burst, from only minutes after the burst until weeks later.

Tsvi Piran

doi:10.1038/422268a


Genomics: Gene expression meets genetics p269

Genetic analyses look for differences in gene sequence that could explain variation in physical traits. Gene-expression studies provide a snapshot of active genes. These approaches are now combined, to great effect.

Ariel Darvasi

doi:10.1038/422269a


Optics: Ado about nothing much? p271

Reports of signals travelling faster than the speed of light have captured the imagination of scientists and laymen alike. But there is an explanation for these effects that leaves Einstein's tenet intact.

Markus Büttiker and Sean Washburn

doi:10.1038/422271a


Developmental biology: A hairy situation p272

A key step in hair-follicle development is the rearrangement of epithelial stem cells. It seems that reduced production of an adhesion protein, through the concerted action of two signalling pathways, is crucial for this process.

Yann Barrandon

doi:10.1038/422272a


Meteorology: Getting the wind up p273

Heike Langenberg

doi:10.1038/422273a


Obituary: Jean Brossel (1918–2003) p274

Franck Laloë

doi:10.1038/422274a


news and views in brief p275

doi:10.1038/422275a


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Brief Communications

Surveillance: Radiographic imaging with cosmic-ray muons p277

Natural background particles could be exploited to detect concealed nuclear materials.

Konstantin N. Borozdin, Gary E. Hogan, Christopher Morris, William C. Priedhorsky, Alexander Saunders, Larry J. Schultz and Margaret E. Teasdale

doi:10.1038/422277a


Palaeo-oceanography: Deepwater variability in the Holocene epoch p277

Delia W. Oppo, Jerry F. McManus and James L. Cullen

doi:10.1038/422277b


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Article

Reduced drag coefficient for high wind speeds in tropical cyclones p279

Mark D. Powell, Peter J. Vickery and Timothy A. Reinhold

doi:10.1038/nature01481

See also: News and Views by Langenberg


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Letters to Nature

Early optical emission from the bold gamma-ray burst of 4 October 2002 p284

D. W. Fox, S. Yost, S. R. Kulkarni, K. Torii, T. Kato, H. Yamaoka, M. Sako, F. A. Harrison, R. Sari, P. A. Price, E. Berger, A. M. Soderberg, S. G. Djorgovski, A. J. Barth, S. H. Pravdo, D. A. Frail, A. Gal-Yam, Y. Lipkin, T. Mauch, C. Harrison and H. Buttery

doi:10.1038/nature01504

See also: News and Views by Piran


Femtosecond X-ray measurement of coherent lattice vibrations near the Lindemann stability limit p287

Klaus Sokolowski-Tinten, Christian Blome, Juris Blums, Andrea Cavalleri, Clemens Dietrich, Alexander Tarasevitch, Ingo Uschmann, Eckhard Förster, Martin Kammler, Michael Horn-von-Hoegen and Dietrich von der Linde

doi:10.1038/nature01490


Phonon interpretation of the 'boson peak' in supercooled liquids p289

T. S. Grigera, V. Martín-Mayor, G. Parisi and P. Verrocchio

doi:10.1038/nature01475


Detection of human influence on sea-level pressure p292

Nathan P. Gillett, Francis W. Zwiers, Andrew J. Weaver and Peter A. Stott

doi:10.1038/nature01487


Enhanced mantle-to-crust rhenium transfer in undegassed arc magmas p294

Weidong Sun, Vickie C. Bennett, Stephen M. Eggins, Vadim S. Kamenetsky and Richard J. Arculus

doi:10.1038/nature01482


Genetics of gene expression surveyed in maize, mouse and man p297

Eric E. Schadt, Stephanie A. Monks, Thomas A. Drake, Aldons J. Lusis, Nam Che, Veronica Colinayo, Thomas G. Ruff, Stephen B. Milligan, John R. Lamb, Guy Cavet, Peter S. Linsley, Mao Mao, Roland B. Stoughton and Stephen H. Friend

doi:10.1038/nature01434

See also: News and Views by Darvasi


Glycine binding primes NMDA receptor internalization p302

Yi Nong, Yue-Qiao Huang, William Ju, Lorraine V. Kalia, Gholamreza Ahmadian, Yu Tian Wang and Michael W. Salter

doi:10.1038/nature01497


Antibody neutralization and escape by HIV-1 p307

Xiping Wei, Julie M. Decker, Shuyi Wang, Huxiong Hui, John C. Kappes, Xiaoyun Wu, Jesus F. Salazar-Gonzalez, Maria G. Salazar, J. Michael Kilby, Michael S. Saag, Natalia L. Komarova, Martin A. Nowak, Beatrice H. Hahn, Peter D. Kwong and George M. Shaw

doi:10.1038/nature01470


Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer p313

D. Neil Watkins, David M. Berman, Scott G. Burkholder, Baolin Wang, Philip A. Beachy and Stephen B. Baylin

doi:10.1038/nature01493


Links between signal transduction, transcription and adhesion in epithelial bud development p317

Colin Jamora, Ramanuj DasGupta, Pawel Kocieniewski and Elaine Fuchs

See also: News and Views by Barrandon


Segregation of receptor and ligand regulates activation of epithelial growth factor receptor p322

Paola D. Vermeer, Lisa A. Einwalter, Thomas O. Moninger, Tatiana Rokhlina, Jeffrey A. Kern, Joseph Zabner and Michael J. Welsh

doi:10.1038/nature01440

See also: News and Views by Mostov & Zegers


The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl p326

Jörg Betschinger, Karl Mechtler and Juergen A. Knoblich

doi:10.1038/nature01486


Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8 p330

Helen Walden, Michael S. Podgorski and Brenda A. Schulman

doi:10.1038/nature01456


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New on the Market

Screen breaks p335

Focusing on high throughput.

doi:10.1038/422335a


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Technology Features

Drug target validation: Hitting the target p341

The route to new therapeutics often ends in costly failure. The secret of success is the rapid and accurate identification of drug targets with true potential, says Caitlin Smith.

Caitlin Smith

doi:10.1038/422341a


A question of form p341

Caitlin Smith

doi:10.1038/422341b


The silent treatment p342

Caitlin Smith

doi:10.1038/422343a


A whole picture p345

Caitlin Smith

doi:10.1038/422345a


table of suppliers p349

doi:10.1038/422349a


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Naturejobs

Prospects

The glory of autonomy p353

Paul Smaglik

doi:10.1038/nj6929-353a


CAREERS AND RECRUITMENT

Victims of success p354

The doubling of public funds for life-science research in the United States has increased the number of postdocs, but it has yet to create significantly more permanent academic positions, says Eugene Russo.

Eugene Russo

doi:10.1038/nj6929-354a


Clouded vision p356

The European Union has dreams of becoming a centralized scientific powerhouse. But first it needs to solve its brain-drain problem. Quirin Schiermeier reports.

Quirin Schiermeier

doi:10.1038/nj6929-356a


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