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Nature 422, 216-225 (13 March 2003) | doi:10.1038/nature01513
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review article From words to literature in structural proteomics
Andrej Sali1, Robert Glaeser2, Thomas Earnest3 & Wolfgang Baumeister4
Abstract
Technical advances on several frontiers have expanded the applicability of existing methods in structural biology and helped close the resolution gaps between them. As a result, we are now poised to integrate structural information gathered at multiple levels of the biological hierarchy — from atoms to cells — into a common framework. The goal is a comprehensive description of the multitude of interactions between molecular entities, which in turn is a prerequisite for the discovery of general structural principles that underlie all cellular processes.
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