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Nature 422, 28-29 (6 March 2003) | doi:10.1038/422028a
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Microfluidics: DNA amplification moves on
Andrew J. deMello
Abstract
The polymerase chain reaction is widely used to amplify samples of DNA for genetic analysis, and fast, high throughput is the ideal. Microscale, chip-based devices are now proving themselves in this arena.
The advent of the polymerase chain reaction (PCR) has hugely accelerated the progress of studies on the genetic structure of a diversity of organisms. PCR is an enzyme-catalysed reaction that allows any nucleic acid sequence to be generated in vitro, and in abundance —hence the term 'DNA amplification'.
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