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Nature 421, 905-906 (27 February 2003) | doi:10.1038/421905a

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Cell polarity: From embryo to axon

Melissa M. Rolls1 & Chris Q. Doe1

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Many cell types in our body, ranging from neurons to the epithelial cells that line the lungs and skin, must be polarized to function properly. The same mechanism may establish the polarity of many of these cells.

How are we to make sense of the complexity of our brains? Filled with billions of nerve cells, each making hundreds or thousands of precise connections to other neurons, this organ develops anew in each of us.

  1. Melissa M. Rolls and Chris Q. Doe are at the Institute of Neuroscience and the Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA.

Correspondence to: Chris Q. Doe1 e-mail: Email: cdoe@uoneuro.uoregon.edu