Figures and Tables : The complete folding pathway of a protein from nanoseconds to microseconds : Nature

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The complete folding pathway of a protein from nanoseconds to microseconds

Ugo Mayor, Nicholas R. Guydosh, Christopher M. Johnson, J. Günter Grossmann, Satoshi Sato, Gouri S. Jas, Stefan M. V. Freund, Darwin O. V. Alonso, Valerie Daggett and Alan R. Fersht

Nature 421, 863-867(20 February 2003)

doi:10.1038/nature01428

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Figure 1

Characterization of wild-type En-HD (WT) and the L16A mutant.

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Figure 2

Protection factors for the amide groups of wild-type En-HD, calculated from the ¹H/²H-exchange experiments at 5 °C.

Full size figure and legend (35K)

Figure 3

Representative structures from the molecular dynamics simulations.

Full size figure and legend (61K)

Figure 4

Kinetics of folding and unfolding.

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Figure 5

The complete folding pathway of En-HD by experiment and simulation.

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