Table of contents
Volume 421 Number 6924 pp675-768
Opinion
Missing the big picture p675
Our understanding of the likely ecological impact of genetically modified crops is incomplete. But these holes in our knowledge are symptomatic of a wider failure adequately to address the science of sustainable agriculture.
doi:10.1038/421675a
News
Shuttle inquiry to piece disaster together from the ground up p677
Declan Butler
doi:10.1038/421677a
Biologists wary that cash up front could mean cuts later p677
Erika Check
doi:10.1038/421677b
DNA study deepens rift over Iceland's genetic heritage p678
Alison Abbott
doi:10.1038/421678a
Cancer fears cast doubts on future of gene therapy p678
Erika Check
doi:10.1038/421678b
London gears up for road congestion charge p679
David Adam
doi:10.1038/421679a
Long-lost wave report sinks asteroid impact theory p679
Rex Dalton
doi:10.1038/421679b
Hints of age bias spur calls for grant reforms p680
David Cyranoski and Keiko Kandachi
doi:10.1038/421680a
Civil war leaves Ivory Coast research in tatters p680
Marieke Degen
doi:10.1038/421680b
India debates results of its first transgenic cotton crop p681
K. S. Jayaraman
doi:10.1038/421681a
Social scientists call for abolition of dishonesty committee p681
Alison Abbott
doi:10.1038/421681b
news feature
Replacing the Space shuttle: On wings and a prayer p684
In the wake of Columbia's loss, NASA's efforts to replace its ageing shuttle fleet are coming under fresh scrutiny. Geoff Brumfiel uncovers a tale of high hopes, false starts and immense technical hurdles.
Geoff Brumfiel
doi:10.1038/421684a
Epigenetics and disease: Altered states p686
Changes to the genome that don't affect DNA sequence may help to explain differences between genetically identical twins. Might these 'epigenetic' phenomena also underlie common diseases? Carina Dennis investigates.
Carina Dennis
doi:10.1038/421686a
Correspondence
Concern about Japan's unclear biotech regulations p689
To exploit genetics research, agencies need to have clearly defined responsibilities.
Kazuo N. Watanabe
doi:10.1038/421689a
Reviewing should be shown in publication list p689
Torben Clausen and Ole Bækgaard Nielsen
doi:10.1038/421689b
Flying into history p689
Jürgen Schmidhuber
doi:10.1038/421689c
Commentary
Toxicology rethinks its central belief p691
Hormesis demands a reappraisal of the way risks are assessed.
doi:10.1038/421691a
Book Reviews
Testing time for Russian lessons p693
Mathematicians say Russia's education reforms are a formula for disaster.
Valery N. Soyfer reviews Obrazovaniye, Kotoroye My Mozhem Poteryat (The Education That We May Lose)
doi:10.1038/421693a
Looking up to the stars p694
Owen Gingerich reviews On the Shoulders of Giants: The Great Works of Physics and Astronomy
doi:10.1038/421694a
A brush with nature p694
doi:10.1038/421694b
A trick of the moonlight p695
Maurice Hershenson reviews The Mystery of the Moon Illusion by Helen Ross and Cornelis Plug
doi:10.1038/421695a
concepts
Thermohaline circulation: The current climate p699
Stefan Rahmstorf
doi:10.1038/421699a
News and Views
Molecular motors: A magnificent machine p701
Electron-microscope studies of the motor protein dynein reveal fascinating details of the movements of its various structural regions. The protein displays a degree of gymnastic ability that is rarely seen.
Richard B. Vallee and Peter Höök
doi:10.1038/421701a
Quantum gravity: The quantum of area? p702
What is the smallest unit of area? To find out, theorists have been wrestling with the notion of quantum black holes. Two independent analyses now seem to lead to the same answer.
John Baez
doi:10.1038/421702a
Inflammation: Border crossings p703
When inflammatory cells leave blood vessels to repair injured tissues, they are helped on their way by the endothelial cells lining the vessels. The invagination and expulsion of endothelial membrane may be the key.
Ann Ager
doi:10.1038/421703a
Global change: Dishing the dirt on coral reefs p705
Sediment is bad news for coral reefs. In Australia, large increases in sedimentation were a by-product of introducing intensive agricultural practices, and that may also apply to other parts of the world.
Julia Cole
doi:10.1038/421705a
Autoimmunity: A case of mistaken identity p706
The interleukin-12 protein has been implicated in autoimmunity, but one complication is that it shares a subunit with a related protein. New work looks at the contribution of these proteins to autoimmunity in mice.
Wendy T. Watford and John J. O'Shea
doi:10.1038/421706a
100 and 50 years ago p707
doi:10.1038/421707a
Astronomy: Hot gas around the Galaxy p708
An extended system of highly ionized gas clouds that surrounds the Milky Way has been detected. This gas may be part of the original matter from which our Galaxy and its nearest neighbours formed.
Amiel Sternberg
doi:10.1038/421708a
news and views in brief p709
doi:10.1038/421709a
Brief Communications
Human behaviour: Adult persistence of head-turning asymmetry p711
A neonatal right-side preference makes a surprising romantic reappearance later in life.
Onur Güntürkün
doi:10.1038/421711a
First paragraph | Full Text | PDF (120K)
Planetary science (communication arising): Volcanism or aqueous alteration on Mars? p711
Victoria E. Hamilton, Philip R. Christensen and Joshua L. Bandfield
doi:10.1038/421711b
First paragraph | Full Text | PDF (120K)
Planetary science (communication arising): Volcanism or aqueous alteration on Mars? p712
Michael B. Wyatt and Harry Y. McSween, Jr
doi:10.1038/421712a
Physiology (communication arising): Why does metabolic rate scale with body size? p713
Geoffrey B. West, Van M. Savage, James Gillooly, Brian J. Enquist, William H. Woodruff and James H. Brown
doi:10.1038/421713a
First paragraph | Full Text | PDF (76K)
Physiology (communication arising): Allometric cascades p713
Jayanth R. Banavar, John Damuth, Amos Maritan and Andrea Rinaldo
doi:10.1038/421713b
First paragraph | Full Text | PDF (76K)
Physiology (communication arising (reply)): Why does metabolic rate scale with body size?/Allometric cascades p714
Charles-A. Darveau, Raul K. Suarez, Russel D. Andrews and Peter W. Hochachka
doi:10.1038/421714a
Article
Dynein structure and power stroke p715
Stan A. Burgess, Matt L. Walker, Hitoshi Sakakibara, Peter J. Knight and Kazuhiro Oiwa
doi:10.1038/nature01377
Abstract | Full Text | PDF (364K) | Supplementary information
See also: News and Views by Vallee & Höök
Letters to Nature
The far-ultraviolet signature of the 'missing' baryons in the Local Group of galaxies p719
Fabrizio Nicastro, Andreas Zezas, Martin Elvis, Smita Mathur, Fabrizio Fiore, Cesare Cecchi-Pestellini, Douglas Burke, Jeremy Drake and Piergiorgio Casella
doi:10.1038/nature01369
First paragraph | Full Text | PDF (226K)
See also: News and Views by Sternberg
Experimental realization of freely propagating teleported qubits p721
Jian-Wei Pan, Sara Gasparoni, Markus Aspelmeyer, Thomas Jennewein and Anton Zeilinger
doi:10.1038/nature01412
First paragraph | Full Text | PDF (321K)
A stable silicon-based allene analogue with a formally sp-hybridized silicon atom p725
S. Ishida, T. Iwamoto, C. Kabuto and M. Kira
doi:10.1038/nature01380
First paragraph | Full Text | PDF (254K) | Supplementary information
Coral record of increased sediment flux to the inner Great Barrier Reef since European settlement p727
Malcolm McCulloch, Stewart Fallon, Timothy Wyndham, Erica Hendy, Janice Lough and David Barnes
doi:10.1038/nature01361
First paragraph | Full Text | PDF (427K) | Supplementary information
See also: News and Views by Cole
A discontinuity in mantle composition beneath the southwest Indian ridge p731
Christine M. Meyzen, Michael J. Toplis, Eric Humler, John N. Ludden and Catherine Mével
doi:10.1038/nature01424
First paragraph | Full Text | PDF (264K) | Supplementary information
Single origin of Malagasy Carnivora from an African ancestor p734
Anne D. Yoder, Melissa M. Burns, Sarah Zehr, Thomas Delefosse, Geraldine Veron, Steven M. Goodman and John J. Flynn
doi:10.1038/nature01303
First paragraph | Full Text | PDF (404K) | Supplementary information
The effect of aggressiveness on the population dynamics of a territorial bird p737
F. Mougeot, S. M. Redpath, F. Leckie and P. J. Hudson
doi:10.1038/nature01395
First paragraph | Full Text | PDF (213K)
Auxin promotes Arabidopsis root growth by modulating gibberellin response p740
Xiangdong Fu and Nicholas P. Harberd
doi:10.1038/nature01387
First paragraph | Full Text | PDF (330K)
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain p744
Daniel J. Cua, Jonathan Sherlock, Yi Chen, Craig A. Murphy, Barbara Joyce, Brian Seymour, Linda Lucian, Wayne To, Sylvia Kwan, Tatyana Churakova, Sandra Zurawski, Maria Wiekowski, Sergio A. Lira, Daniel Gorman, Robert A. Kastelein and Jonathon D. Sedgwick
doi:10.1038/nature01355
First paragraph | Full Text | PDF (435K) | Supplementary information
See also: News and Views by Watford & O'Shea
Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis p748
Zahra Mamdouh, Xia Chen, Lynda M. Pierini, Frederick R. Maxfield and William A. Muller
doi:10.1038/nature01300
First paragraph | Full Text | PDF (538K) | Supplementary information
See also: News and Views by Ager
Cdc42 regulates GSK-3
and adenomatous polyposis coli to control cell polarity p753
Sandrine Etienne-Manneville and Alan Hall
doi:10.1038/nature01423
First paragraph | Full Text | PDF (336K)
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab p756
Hyun-Soo Cho, Karen Mason, Kasra X. Ramyar, Ann Marie Stanley, Sandra B. Gabelli, Dan W. Denney, Jr and Daniel J. Leahy
doi:10.1038/nature01392
First paragraph | Full Text | PDF (335K) | Supplementary information
Crystal structure of the specificity domain of ribonuclease P p760
Andrey S. Krasilnikov, Xiaojing Yang, Tao Pan and Alfonso Mondragón
doi:10.1038/nature01386
First paragraph | Full Text | PDF (379K) | Supplementary information
retraction: Metal–insulator transition in chains with correlated disorder p764
Pedro Carpena, Pedro Bernaola-Galván, Plamen Ch. Ivanov and H. Eugene Stanley
doi:10.1038/nature01288
retraction: A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants p764
J. Taub, J. F. Lau, C. Ma, J. H. Hahn, R. Hoque, J. Rothblatt and M. Chalfie
doi:10.1038/nature01425
erratum: Wave-like properties of solar supergranulation p764
L. Gizon, T. L. Duvall, Jr and J. Schou
doi:10.1038/nature01426
Naturejobs
ProspectsA moving story p765
Paul Smaglik
doi:10.1038/nj6924-765a
POSTDOCS
Location, location, location p766
When a postdoc has a choice about where to go for a fellowship, how much do non-scientific factors like cost of living weigh on the final decision? Karen Kreeger investigates.
Karen Kreeger
doi:10.1038/nj6924-766a
movers
Movers p768
doi:10.1038/nj6924-768a
Correction
Correction p768
doi:10.1038/nj6924-768b
