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Nature 421, 686-688 (13 February 2003) | doi:10.1038/421686a

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Epigenetics and disease: Altered states

Carina Dennis1

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Changes to the genome that don't affect DNA sequence may help to explain differences between genetically identical twins. Might these 'epigenetic' phenomena also underlie common diseases? Carina Dennis investigates.

Marie and Jo — not their real names — are twins, genetically identical and raised in a happy home. Growing up, both enjoyed sport and art, were equally good at school, and appeared similar in almost every respect.