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From the following article:

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

Daniel J. Cua, Jonathan Sherlock, Yi Chen, Craig A. Murphy, Barbara Joyce, Brian Seymour, Linda Lucian, Wayne To, Sylvia Kwan, Tatyana Churakova, Sandra Zurawski, Maria Wiekowski, Sergio A. Lira, Daniel Gorman, Robert A. Kastelein and Jonathon D. Sedgwick

Nature 421, 744-748(13 February 2003)

doi:10.1038/nature01355

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Figure 1

Generation of IL-23-deficient mice.

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Figure 2

IL-23, and not IL-12, is required for the induction of EAE.

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Figure 3

TH1 cells are induced in p19-/- but not p35-/- mice.

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Figure 4

TH1 cells and inflammatory macrophages enter the CNS of MOG-immunized p19-/- mice but fail to induce EAE.

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Figure 5

IL-23, and not IL-12, induces IL-1beta and TNF mRNA expression in macrophages.

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