Table of contents
Volume 421 Number 6923 pp559-673
Opinion
Where now for NASA? p559
The loss of the space shuttle Columbia and its seven astronauts has cast a shadow over America's space agency. But it also presents an opportunity to redirect the US space programme towards the lofty goal of exploration.
doi:10.1038/421559a
News
Columbia explosion may trigger fatal delays for space station p561
Tony Reichhardt
doi:10.1038/421561a
NASA sets up dual probes into shuttle accident p561
Geoff Brumfiel
doi:10.1038/421561b
Science had rare leading role in ill-starred shuttle mission p562
David Adam
doi:10.1038/421562a
Fusion project back on track as US returns to the fold p563
Geoff Brumfiel
doi:10.1038/421563a
Fading support ends Europe's dreams of neutron supremacy p563
Quirin Schiermeier
doi:10.1038/421563b
Fury at plan to split historic biology archive p564
Rex Dalton
doi:10.1038/421564a
Harvard team suggests route to better bioterror alerts p564
Jonathan Knight
doi:10.1038/421564b
Science feels the pinch as Bush budget targets defence p565
Erika Check
doi:10.1038/421565a
news feature
Crop improvement: A dying breed p568
Public-sector research into classical crop breeding is withering, supplanted by 'sexier' high-tech methods. But without breeders' expertise, molecular-genetic approaches might never bear fruit. Jonathan Knight reports.
Jonathan Knight
doi:10.1038/421568a
Microwave chemistry: Out of the kitchen p571
Designer microwave ovens that can heat reactants in record time are heralding a quiet revolution in chemical synthesis. David Adam feels the heat.
David Adam
doi:10.1038/421571a
Correspondence
Time for bioethics and business to start talking p573
Commerce and idealism need not be mutually exclusive.
Rahul K. Dhanda
doi:10.1038/421573a
Tools for modelling biological processes p573
John Keane
doi:10.1038/421573b
Complexity may teach us a simple lesson p573
Michael Sierk
doi:10.1038/421573c
Commentary
Fuel for thought p575
Stanford has signed up for a ride on a tiger. Will it survive the journey intact?
doi:10.1038/421575a
Book Reviews
Knowledge is power p577
Self-interest shaped the global agreement on intellectual-property rights.
Sandy Thomas reviews Information Feudalism: Who Owns the Knowledge Economy? by Peter Drahos and John Braithwaite
doi:10.1038/421577a
Science laws and science lore p578
Walter Gratzer reviews Cassell's Laws of Nature: An A–Z of Laws and Principles Governing the Workings of Our Universe/The Nature of Science: An A–Z Guide to the Laws and Principles Governing Our Universe by James Trefil
doi:10.1038/421578a
New in paperback p578
doi:10.1038/421578b
Mergers and acquisitions p579
Steven A. Frank reviews Darwin's Blind Spot: Evolution Beyond Natural Selection by Frank Ryan
doi:10.1038/421579a
Science in culture p580
Alison Abbott reviews
doi:10.1038/421580a
News and Views
Conservation biology: Parasites lost p585
Why do some plants and animals become pests when they are introduced to new areas? Part of the answer seems to be that they have left most of their parasites behind, gaining vigour as a consequence.
Keith Clay
doi:10.1038/421585a
Applied physics: Solar cells to dye for p586
The idea of producing electricity from sunlight is attractive, but in practice the technology to do so is expensive. A new device, moving away from the traditional silicon design, shows promise.
Michael Grätzel
doi:10.1038/421586a
Human genetics: Lost anchors cost lives p587
Mutations in ion-transport proteins can destabilize the electrical activity of the heart, causing sudden death. It now seems that mutations in a protein that anchors ion transporters to cell membranes can have the same effect.
Stanley Nattel
doi:10.1038/421587a
100 and 50 years ago p589
doi:10.1038/421589a
Earth science: Ins and outs on the ocean floor p590
Researchers investigating heat exchange between the ocean floor and the ocean have various long-standing issues to tackle. The latest measurements of heat flux in hydrothermally active crust will add to these debates.
John G. Sclater
doi:10.1038/421590a
Ecology: Shady deals with lichens p591
In tropical forests, many species of lichen gain a place in the sun by living on the leaves of other plants. It seems they can do so without compromising the photosynthetic capacity of their host.
Peter D. Moore
doi:10.1038/421591a
Attophysics: Ultrafast control p593
The successes of two pioneering groups are now brought together to create trains of identical ultrashort laser pulses that can control what's happening inside an atom.
Philip H. Bucksbaum
doi:10.1038/421593a
Cancer: More than skin deep p594
Activation of the nuclear factor NF-
B has been linked with many human cancers. But in tumours of some tissues this molecule is inactive. New work examines how turning off NF-B promotes cancer in one tissue, the skin.
Diana Bolotin and Elaine Fuchs
doi:10.1038/421594a
Correction p595
doi:10.1038/421595a
Obituary: Grote Reber (1911–2002) p596
K. I. Kellermann
doi:10.1038/421596a
news and views in brief p597
doi:10.1038/421597a
Brief Communications
Fish migration: Patagonian toothfish found off Greenland p599
This catch is evidence of transequatorial migration by a cold-water Antarctic fish.
Peter Rask Møller, Jørgen G. Nielsen and Inge Fossen
doi:10.1038/421599a
First paragraph | Full Text | PDF (311K)
Materials: Ultrahard polycrystalline diamond from graphite p599
Tetsuo Irifune, Ayako Kurio, Shizue Sakamoto, Toru Inoue and Hitoshi Sumiya
doi:10.1038/421599b
First paragraph | Full Text | PDF (311K)
Correction p600
doi:10.1038/421600a
Article
The DNA sequence and analysis of human chromosome 14 p601
Roland Heilig, Ralph Eckenberg, Jean-Louis Petit, Núria Fonknechten, Corinne Da Silva, Laurence Cattolico, Michaël Levy, Valérie Barbe, Véronique de Berardinis, Abel Ureta-Vidal, Eric Pelletier, Virginie Vico, Véronique Anthouard, Lee Rowen, Anup Madan, Shizhen Qin, Hui Sun, Hui Du, Kymberlie Pepin, François Artiguenave, Catherine Robert, Corinne Cruaud, Thomas Brüls, Olivier Jaillon, Lucie Friedlander, Gaelle Samson, Philippe Brottier, Susan Cure, Béatrice Ségurens, Franck Anière, Sylvie Samain, Hervé Crespeau, Nissa Abbasi, Nathalie Aiach, Didier Boscus, Rachel Dickhoff, Monica Dors, Ivan Dubois, Cynthia Friedman, Michel Gouyvenoux, Rose James, Anuradha Madan, Barbara Mairey–Estrada, Sophie Mangenot, Nathalie Martins, Manuela Ménard, Sophie Oztas, Amber Ratcliffe, Tristan Shaffer, Barbara Trask, Benoit Vacherie, Chadia Bellemere, Caroline Belser, Marielle Besnard-Gonnet, Delphine Bartol–Mavel, Magali Boutard, Stéphanie Briez-Silla, Stephane Combette, Virginie Dufossé-Laurent, Carolyne Ferron, Christophe Lechaplais, Claudine Louesse, Delphine Muselet, Ghislaine Magdelenat, Emilie Pateau, Emmanuelle Petit, Peggy Sirvain-Trukniewicz, Arnaud Trybou, Nathalie Vega-Czarny, Elodie Bataille, Elodie Bluet, Isabelle Bordelais, Maria Dubois, Corinne Dumont, Thomas Guérin, Sébastien Haffray, Rachid Hammadi, Jacqueline Muanga, Virginie Pellouin, Dominique Robert, Edith Wunderle, Gilbert Gauguet, Alice Roy, Laurent Sainte-Marthe, Jean Verdier, Claude Verdier-Discala, LaDeana Hillier, Lucinda Fulton, John McPherson, Fumihiko Matsuda, Richard Wilson, Claude Scarpelli, Gábor Gyapay, Patrick Wincker, William Saurin, Francis Quétier, Robert Waterston, Leroy Hood and Jean Weissenbach
doi:10.1038/nature01348
Abstract | Full Text | PDF (377K) | Supplementary information
Letters to Nature
Disruption of fragmented parent bodies as the origin of asteroid families p608
Patrick Michel, Willy Benz and Derek C. Richardson
doi:10.1038/nature01364
First paragraph | Full Text | PDF (299K)
Attosecond control of electronic processes by intense light fields p611
A. Baltu
ka,
Th. Udem,
M. Uiberacker,
M. Hentschel,
E. Goulielmakis,
Ch. Gohle,
R. Holzwarth,
V. S. Yakovlev,
A. Scrinzi,
T. W. Hänsch
and
F. Krausz
doi:10.1038/nature01414
First paragraph | Full Text | PDF (557K)
See also: News and Views by Bucksbaum
A photovoltaic device structure based on internal electron emission p616
Eric W. McFarland and Jing Tang
doi:10.1038/nature01316
First paragraph | Full Text | PDF (199K)
See also: News and Views by Grätzel
Hydrothermal recharge and discharge across 50 km guided by seamounts on a young ridge flank p618
A. T. Fisher, E. E. Davis, M. Hutnak, V. Spiess, L. Zühlsdorff, A. Cherkaoui, L. Christiansen, K. Edwards, R. Macdonald, H. Villinger, M. J. Mottl, C. G. Wheat and K. Becker
doi:10.1038/nature01352
First paragraph | Full Text | PDF (453K)
See also: News and Views by Sclater
Constant elevation of southern Tibet over the past 15 million years p622
Robert A. Spicer, Nigel B. W. Harris, Mike Widdowson, Alexei B. Herman, Shuangxing Guo, Paul J. Valdes, Jack A. Wolfe and Simon P. Kelley
doi:10.1038/nature01356
First paragraph | Full Text | PDF (214K) | Supplementary information
Release of invasive plants from fungal and viral pathogens p625
Charles E. Mitchell and Alison G. Power
doi:10.1038/nature01317
First paragraph | Full Text | PDF (296K)
See also: News and Views by Clay
Introduced species and their missing parasites p628
Mark E. Torchin, Kevin D. Lafferty, Andrew P. Dobson, Valerie J. McKenzie and Armand M. Kuris
doi:10.1038/nature01346
First paragraph | Full Text | PDF (211K) | Supplementary information
See also: News and Views by Clay
The contribution of Shaker K+ channels to the information capacity of Drosophila photoreceptors p630
Jeremy E. Niven, Mikko Vähäsöyrinki, Mika Kauranen, Roger C. Hardie, Mikko Juusola and Matti Weckström
doi:10.1038/nature01384
First paragraph | Full Text | PDF (387K) | Supplementary information
Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death p634
Peter J. Mohler, Jean-Jacques Schott, Anthony O. Gramolini, Keith W. Dilly, Silvia Guatimosim, William H. duBell, Long-Sheng Song, Karine Haurogné, Florence Kyndt, Mervat E. Ali, Terry B. Rogers, W. J. Lederer, Denis Escande, Herve Le Marec and Vann Bennett
doi:10.1038/nature01335
First paragraph | Full Text | PDF (671K) | Supplementary information
See also: News and Views by Nattel
NF-
B blockade and oncogenic Ras trigger invasive human epidermal neoplasia p639
Maya Dajee, Mirella Lazarov, Jennifer Y. Zhang, Ti Cai, Cheryl L. Green, Alan J. Russell, M. Peter Marinkovich, Shiying Tao, Qun Lin, Yoshiaki Kubo and Paul A. Khavari
doi:10.1038/nature01283
First paragraph | Full Text | PDF (566K) | Supplementary information
See also: News and Views by Bolotin & Fuchs
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing p643
Kwok-Kin Wong, Richard S. Maser, Robert M. Bachoo, Jayant Menon, Daniel R. Carrasco, Yansong Gu, Frederick W. Alt and Ronald A. DePinho
doi:10.1038/nature01385
First paragraph | Full Text | PDF (518K) | Supplementary information
Plants lacking the main light-harvesting complex retain photosystem II macro-organization p648
A. V. Ruban, M. Wentworth, A. E. Yakushevska, J. Andersson, P. J. Lee, W. Keegstra, J. P. Dekker, E. J. Boekema, S. Jansson and P. Horton
doi:10.1038/nature01344
First paragraph | Full Text | PDF (383K)
Structure and catalytic mechanism of the human histone methyltransferase SET7/9 p652
Bing Xiao, Chun Jing, Jonathan R. Wilson, Philip A. Walker, Nishi Vasisht, Geoff Kelly, Steven Howell, Ian A. Taylor, G. Michael Blackburn and Steven J. Gamblin
doi:10.1038/nature01378
First paragraph | Full Text | PDF (435K) | Supplementary information
corrigendum: Contemporary fisherian life-history evolution in small salmonid populations p656
Mikko T. Koskinen, Thrond O. Haugen and Craig R. Primmer
doi:10.1038/nature01347
New on the Market
DNA on the slide p657
Microarray readers, tissue microarrays and high-throughput screening.
doi:10.1038/421657a
Technology Features
Lab automation and robotics: Automation on the move p661
The insatiable demands of the pharmaceutical industry are helping to drive labs into the automated world of industrial production lines. Tim Chapman joins the quest for speed.
Tim Chapman
doi:10.1038/421661a
A structured approach p661
Tim Chapman
doi:10.1038/421661b
Cultural revolution p663
Tim Chapman
doi:10.1038/421663a
Sampled delights p665
Tim Chapman
doi:10.1038/421665a
table of suppliers p668
doi:10.1038/421668a
Naturejobs
ProspectsA cold shoulder for stocks p671
Paul Smaglik
doi:10.1038/nj6923-671a
REGIONS
Taiwan: Biotech vision p672
David Cyranoski
doi:10.1038/nj6923-672a
First paragraph | Full Text | PDF (244K)
