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Nature 421, 594-595 (6 February 2003) | doi:10.1038/421594a
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Assistant Professor and Associate Professor
- Massachusetts General Hospital/ Harvard Medical School
- Charlestown, MA
Gastroenterologist
- Wayne State University
- Detroit, Michigan, USA
Cancer: More than skin deep
Diana Bolotin & Elaine Fuchs
Abstract
Activation of the nuclear factor NF-
B has been linked with many human cancers. But in tumours of some tissues this molecule is inactive. New work examines how turning off NF-B promotes cancer in one tissue, the skin.
What do cell death, cell proliferation, immune responses and tumour development have in common? The answer is that they are just a few of the many biological processes in mammals that are regulated by proteins of the nuclear factor NF-B family1, 2.
- Diana Bolotin and Elaine Fuchs are at the Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, Box 300, New York, New York 10021-6399, USA.
Correspondence to: Elaine Fuchs e-mail: Email: fuchs@mail.rockefeller.edu
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