Mutations in ion-transport proteins can destabilize the electrical activity of the heart, causing sudden death. It now seems that mutations in a protein that anchors ion transporters to cell membranes can have the same effect.
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Nattel, S. Lost anchors cost lives. Nature 421, 587–589 (2003). https://doi.org/10.1038/421587a
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DOI: https://doi.org/10.1038/421587a