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TY  - JOUR
TI  - A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
JO  - Cell
PY  - 1993///
VL  - 72
SP  - 971
EP  - 983
ER  - 

TY  - JOUR
AU  - Wellington, C. L.
TI  - Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells
JO  - J. Biol. Chem.
PY  - 2000///
VL  - 275
SP  - 19831
EP  - 19838
M3  - 10.1074/jbc.M001475200
N1  - 10.1074/jbc.M001475200
UR  - http://dx.doi.org/10.1074/jbc.M001475200
ER  - 

TY  - JOUR
AU  - Kim, Y. J.
TI  - Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
JO  - Proc. Natl Acad. Sci. USA
PY  - 2001///
VL  - 98
SP  - 12784
EP  - 12789
M3  - 10.1073/pnas.221451398
N1  - 10.1073/pnas.221451398
UR  - http://dx.doi.org/10.1073/pnas.221451398
ER  - 

TY  - JOUR
AU  - Lunkes, A.
TI  - Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions
JO  - Mol. Cell
PY  - 2002///
VL  - 10
SP  - 259
EP  - 269
M3  - 10.1016/S1097-2765(02)00602-0
N1  - 10.1016/S1097-2765(02)00602-0
UR  - http://dx.doi.org/10.1016/S1097-2765(02)00602-0
ER  - 

TY  - JOUR
AU  - Wellington, C. L.
TI  - Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease
JO  - J. Neurosci.
PY  - 2002///
VL  - 22
SP  - 7862
EP  - 7872
ER  - 

TY  - JOUR
AU  - Perutz, M.
TI  - Polar zippers: their role in human disease
JO  - Protein Sci.
PY  - 1994///
VL  - 3
SP  - 1629
EP  - 1637
ER  - 

TY  - JOUR
AU  - Mangiarini, L.
TI  - Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
JO  - Cell
PY  - 1996///
VL  - 87
SP  - 493
EP  - 506
M3  - 10.1016/S0092-8674(00)81369-0
N1  - 10.1016/S0092-8674(00)81369-0
UR  - http://dx.doi.org/10.1016/S0092-8674(00)81369-0
ER  - 

TY  - JOUR
AU  - Klunk, W. E.
AU  - Pettegrew, J. W.
AU  - Abraham, D. J.
TI  - Quantitative evaluation of Congo red binding to amyloid-like proteins with a [beta]-pleated sheet conformation
JO  - J. Histochem. Cytochem.
PY  - 1989///
VL  - 37
SP  - 1273
EP  - 1281
ER  - 

TY  - JOUR
AU  - Carter, D. B.
AU  - Chou, K. C.
TI  - A model for structure-dependent binding of Congo red to Alzheimer [beta]-amyloid fibrils
JO  - Neurobiol. Aging
PY  - 1998///
VL  - 19
SP  - 37
EP  - 40
M3  - 10.1016/S0197-4580(97)00164-4
N1  - 10.1016/S0197-4580(97)00164-4
UR  - http://dx.doi.org/10.1016/S0197-4580(97)00164-4
ER  - 

TY  - JOUR
AU  - Heiser, V.
TI  - Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy
JO  - Proc. Natl Acad. Sci. USA
PY  - 2000///
VL  - 97
SP  - 6739
EP  - 6744
M3  - 10.1073/pnas.110138997
N1  - 10.1073/pnas.110138997
UR  - http://dx.doi.org/10.1073/pnas.110138997
ER  - 

TY  - JOUR
AU  - Caughey, B.
AU  - Raymond, G. J.
TI  - Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells
JO  - J. Virol.
PY  - 1993///
VL  - 67
SP  - 643
EP  - 650
ER  - 

TY  - JOUR
AU  - Howlett, D. R.
AU  - George, A. R.
AU  - Owen, D. E.
AU  - Ward, R. V.
AU  - Markwell, R. E.
TI  - Common structural features determine the effectiveness of carvedilol, daunomycin and rolitetracycline as inhibitors of Alzheimer [beta]-amyloid fibril formation
JO  - Biochem. J.
PY  - 1999///
VL  - 343
SP  - 419
EP  - 423
M3  - 10.1042/0264-6021:3430419
N1  - 10.1042/0264-6021:3430419
UR  - http://dx.doi.org/10.1042/0264-6021:3430419
ER  - 

TY  - JOUR
AU  - Klunk, W. E.
AU  - Debnath, M. L.
AU  - Pettegrew, J. W.
TI  - Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe
JO  - Neurobiol. Aging
PY  - 1995///
VL  - 16
SP  - 541
EP  - 548
M3  - 10.1016/0197-4580(95)00058-M
N1  - 10.1016/0197-4580(95)00058-M
UR  - http://dx.doi.org/10.1016/0197-4580(95)00058-M
ER  - 

TY  - JOUR
AU  - Sanchez, I.
TI  - Caspase-8 is required for cell death induced by expanded polyglutamine repeats
JO  - Neuron
PY  - 1999///
VL  - 22
SP  - 623
EP  - 633
M3  - 10.1016/S0896-6273(00)80716-3
N1  - 10.1016/S0896-6273(00)80716-3
UR  - http://dx.doi.org/10.1016/S0896-6273(00)80716-3
ER  - 

TY  - JOUR
AU  - Beal, M. F.
AU  - Hyman, B. T.
AU  - Koroshetz, W.
TI  - Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?
JO  - Trends Neurosci.
PY  - 1993///
VL  - 16
SP  - 125
EP  - 131
M3  - 10.1016/0166-2236(93)90117-5
N1  - 10.1016/0166-2236(93)90117-5
UR  - http://dx.doi.org/10.1016/0166-2236(93)90117-5
ER  - 

TY  - JOUR
AU  - Deckwerth, T. L.
AU  - Johnson, E. M.
TI  - Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor
JO  - J. Cell Biol.
PY  - 1993///
VL  - 123
SP  - 1207
EP  - 1222
M3  - 10.1083/jcb.123.5.1207
N1  - 10.1083/jcb.123.5.1207
UR  - http://dx.doi.org/10.1083/jcb.123.5.1207
ER  - 

TY  - JOUR
AU  - Jaattela, M.
AU  - Wissing, D.
AU  - Kokholm, K.
AU  - Kallunki, T.
AU  - Egeblad, M.
TI  - Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases
JO  - EMBO J.
PY  - 1998///
VL  - 17
SP  - 6124
EP  - 6134
M3  - 10.1093/emboj/17.21.6124
N1  - 10.1093/emboj/17.21.6124
UR  - http://dx.doi.org/10.1093/emboj/17.21.6124
ER  - 

TY  - JOUR
AU  - Wyttenbach, A.
TI  - Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease
JO  - Proc. Natl Acad. Sci. USA
PY  - 2000///
VL  - 97
SP  - 2898
EP  - 2903
M3  - 10.1073/pnas.97.6.2898
N1  - 10.1073/pnas.97.6.2898
UR  - http://dx.doi.org/10.1073/pnas.97.6.2898
ER  - 

TY  - JOUR
AU  - Chai, Y.
AU  - Koppenhafer, S. L.
AU  - Bonini, N. M.
AU  - Paulson, H. L.
TI  - Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease
JO  - J. Neurosci.
PY  - 1999///
VL  - 19
SP  - 10338
EP  - 10347
ER  - 

TY  - JOUR
AU  - Kazemi-Esfarjani, P.
AU  - Benzer, S.
TI  - Genetic suppression of polyglutamine toxicity in Drosophila
JO  - Science
PY  - 2000///
VL  - 287
SP  - 1837
EP  - 1840
M3  - 10.1126/science.287.5459.1837
N1  - 10.1126/science.287.5459.1837
UR  - http://dx.doi.org/10.1126/science.287.5459.1837
ER  - 

TY  - JOUR
AU  - Hazeki, N.
AU  - Tukamoto, T.
AU  - Goto, J.
AU  - Kanazawa, I.
TI  - Formic acid dissolves aggregates of an N-terminal huntingtin fragment containing an expanded polyglutamine tract: applying to quantification of protein components of the aggregates
JO  - Biochem. Biophys. Res. Commun.
PY  - 2000///
VL  - 277
SP  - 386
EP  - 393
M3  - 10.1006/bbrc.2000.3682
N1  - 10.1006/bbrc.2000.3682
UR  - http://dx.doi.org/10.1006/bbrc.2000.3682
ER  - 

TY  - JOUR
AU  - Moulder, K. L.
AU  - Onodera, O.
AU  - Burke, J. R.
AU  - Strittmatter, W. J.
AU  - Johnson, E. M.
TI  - Generation of neuronal intranuclear inclusions by polyglutamine-GFP: analysis of inclusion clearance and toxicity as a function of polyglutamine length
JO  - J. Neurosci.
PY  - 1999///
VL  - 19
SP  - 705
EP  - 715
ER  - 

TY  - JOUR
AU  - Cummings, C. J.
TI  - Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1
JO  - Nature Genet.
PY  - 1998///
VL  - 19
SP  - 148
EP  - 154
M3  - 10.1038/502
N1  - 10.1038/502
UR  - http://dx.doi.org/10.1038/502
ER  - 

TY  - JOUR
AU  - Bence, N. F.
AU  - Sampat, R. M.
AU  - Kopito, R. R.
TI  - Impairment of the ubiquitin-proteasome system by protein aggregation
JO  - Science
PY  - 2001///
VL  - 292
SP  - 1552
EP  - 1555
M3  - 10.1126/science.292.5521.1552
N1  - 10.1126/science.292.5521.1552
UR  - http://dx.doi.org/10.1126/science.292.5521.1552
ER  - 

TY  - JOUR
AU  - Hurlbert, M. S.
TI  - Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes
JO  - Diabetes
PY  - 1999///
VL  - 48
SP  - 649
EP  - 651
ER  - 

TY  - JOUR
AU  - Farrer, L. A.
TI  - Diabetes mellitus in Huntington disease
JO  - Clin. Genet.
PY  - 1985///
VL  - 27
SP  - 62
EP  - 67
ER  - 

TY  - JOUR
AU  - Li, H.
AU  - Li, S. H.
AU  - Johnston, H.
AU  - Shelbourne, P. F.
AU  - Li, X. J.
TI  - Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity
JO  - Nature Genet.
PY  - 2000///
VL  - 25
SP  - 385
EP  - 389
M3  - 10.1038/78054
N1  - 10.1038/78054
UR  - http://dx.doi.org/10.1038/78054
ER  - 

TY  - JOUR
AU  - DiFiglia, M.
TI  - Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
JO  - Science
PY  - 1997///
VL  - 277
SP  - 1990
EP  - 1993
M3  - 10.1126/science.277.5334.1990
N1  - 10.1126/science.277.5334.1990
UR  - http://dx.doi.org/10.1126/science.277.5334.1990
ER  - 

TY  - JOUR
AU  - Onodera, O.
TI  - Oligomerization of expanded-polyglutamine domain fluorescent fusion proteins in cultured mammalian cells
JO  - Biochem. Biophys. Res. Commun.
PY  - 1997///
VL  - 238
SP  - 599
EP  - 605
M3  - 10.1006/bbrc.1997.7337
N1  - 10.1006/bbrc.1997.7337
UR  - http://dx.doi.org/10.1006/bbrc.1997.7337
ER  - 

TY  - JOUR
AU  - Carter, R. J.
TI  - Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation
JO  - J. Neurosci.
PY  - 1999///
VL  - 19
SP  - 3248
EP  - 3257
ER  - 

