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Nature 420, 669-673 (12 December 2002) | doi:10.1038/nature01205;
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The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel
Mechanosensory transduction in touch receptor neurons is believed to be mediated by DEG/ENaC (degenerin/epithelial Na|[plus]| channel) proteins in nematodes and mammals. In the nematode Caenorhabditis elegans, gain-of-function mutations in the degenerin genes mec-4 and mec-10 (denoted mec-4(d) and mec-10(d), respectively) cause degeneration of the touch cells.
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