Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 420, 613-614 (12 December 2002) | doi:10.1038/420613a
Open Innovation Challenges
-
Methods to Analyze Consumer Emotions
The Seeker is looking for methods to analyze consumer emotions. This Challenge requires only a writ...
-
Optimizing Sub-cellular Localization Tags
The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression....
- More Challenges
- Powered by:
nature jobs
Copy Editor
- Indegene Lifesystems Pvt. Ltd
- Bengaluru 560 071 India
System Engineer (Mechanical)
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
Structural biology: On the wings of inhibition
Jeffrey L. Wrana
Abstract
Growth factors regulate cell behaviour, and are kept in check by inhibitors. The structure of a complex of two such proteins shows that they form back-to-back butterflies, with the inhibitor's wings stretching to embrace its partner.
Multicellular organisms use a balance of secreted growth-factor proteins and their inhibitors to coordinate cell behaviour, thereby regulating the development of embryos and maintaining the status quo in adult tissues. On page 636 of this issue, Groppe and colleagues1 describe the structure of one such growth factor, bone morphogenetic protein 7 (BMP-7), in a complex with its inhibitor, the Noggin protein.
To read this story in full you will need to login or make a payment (see right).
