FIGURE 16. Structure of a new homologue of dystrophin as predicted on mouse chromosome 1 and human chromosome 2.

Mouse and human gene structures are shown in blue on the chromosomes (pink). The mouse intron marked with an asterisk was verified by RT–PCR from primers complementary to the flanking exons followed by direct product sequencing³²⁷. Regions of high-scoring alignment to the entire other genome (computed before gene predictions and identification of predicted orthologues) are shown in yellow. Note the weak correspondence between predicted exons and blocks of high-scoring whole-genome alignment. Nonetheless, the predicted proteins considered in isolation show good alignment across several splice sites.