FIGURE 5. Association between a single haplotype and the albinism phenotype caused by a mutation at the tyrosinase locus20.
From the following article:
The mosaic structure of variation in the laboratory mouse genome
Claire M. Wade, Edward J. Kulbokas, III, Andrew W. Kirby, Michael C. Zody, James C. Mullikin, Eric S. Lander, Kerstin Lindblad-Toh and Mark J. Daly
Nature 420, 574-578(5 December 2002)
doi:10.1038/nature01252

Columns show SNPs discovered in ten 500-bp assays with positions (kb) relative to the centre of the genomic segment containing the gene (GenBank accession GI:12852585). The causal mutation (Cys103Ser) is located at +32.6 kb. The association between phenotype and ancestral haplotype for 12 strains would be sufficient to identify a haplotype background and 'critical region' of
500 kb (including the assays from -100 kb before Tyr to 200 kb after Tyr) likely to contain the albinism mutation.
