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Nature 420, 373-374 (28 November 2002) | doi:10.1038/420373a
Open Innovation Challenges
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Protect Enzyme from In Planta Degradation
A proposal for stable expression of an enzyme in corn seed is desired.
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Fast Growth of Transformed Soybean Shoots
A method for accelerating growth of soybean shoots is desired.
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Scientist (2 positions)
- Philip Morris International (PMI)
- Singapore
BBSRC Industrial CASE Studentship
- University College London
- London WC1E 6JF United Kingdom
Circadian rhythms: The cancer connection
Michael Rosbash1 & Joseph S. Takahashi2
Abstract
The Per2 gene is a core component of the circadian clock in mammals. It now seems that the mouse Per2 gene is also involved in suppressing tumours, through other genes that affect cell proliferation and death.
If the mantra in real estate is 'location, location, location', in genetics it would be 'phenotype, phenotype, phenotype'. There is simply no substitute for a detailed phenotypic analysis of a mutant strain (study of the overt manifestation of a mutated gene in the organism).
- Michael Rosbash is at the Howard Hughes Medical Institute, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA.
e-mail: Email: rosbash@brandeis.edu - Joseph S. Takahashi is at the Howard Hughes Medical Institute, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA.
e-mail: Email: j-takahashi@northwestern.edu
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