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Nature 420, 373-374 (28 November 2002) | doi:10.1038/420373a

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Circadian rhythms: The cancer connection

Michael Rosbash1 & Joseph S. Takahashi2

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The Per2 gene is a core component of the circadian clock in mammals. It now seems that the mouse Per2 gene is also involved in suppressing tumours, through other genes that affect cell proliferation and death.

If the mantra in real estate is 'location, location, location', in genetics it would be 'phenotype, phenotype, phenotype'. There is simply no substitute for a detailed phenotypic analysis of a mutant strain (study of the overt manifestation of a mutated gene in the organism).

  1. Michael Rosbash is at the Howard Hughes Medical Institute, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA.
    e-mail: Email: rosbash@brandeis.edu
  2. Joseph S. Takahashi is at the Howard Hughes Medical Institute, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA.
    e-mail: Email: j-takahashi@northwestern.edu