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Nature 420, 279 (21 November 2002) | doi:10.1038/420279a

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Cancer: Super p53

Barbara Marte

One of the most intensively studied of cellular molecules, the p53 protein is well known for its role as a tumour suppressor: it helps to protect against cancer by regulating the response of our cells to damage and stress. A common characteristic of human cancers is the mutation, and hence inactivation, of p53, which predisposes organisms to tumours.