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insight
Nature 420, 206-210 (14 November 2002) | doi:10.1038/nature01254
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Dermapathologist
- Indiana University School of Medicine
- Indiana, USA
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- The University of Texas Southwestern Medical Center
- Dallas, TX 75390-9148 United States
overview Computational systems biology
Hiroaki Kitano
Abstract
To understand complex biological systems requires the integration of experimental and computational research — in other words a systems biology approach. Computational biology, through pragmatic modelling and theoretical exploration, provides a powerful foundation from which to address critical scientific questions head-on. The reviews in this Insight cover many different aspects of this energetic field, although all, in one way or another, illuminate the functioning of modular circuits, including their robustness, design and manipulation. Computational systems biology addresses questions fundamental to our understanding of life, yet progress here will lead to practical innovations in medicine, drug discovery and engineering.
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