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Nature 420, 138-139 (14 November 2002) | doi:10.1038/420138a
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Developmental biology: First come, first served
Rolf Zeller1 & Jacqueline Deschamps2
Abstract
It is more than a decade since the discovery that vertebrate Hox genes are arranged and expressed in the same order as the body parts they help to produce. New work looks at how this is achieved in fingers and toes.
Arguably one of the most interesting aspects of developmental biology concerns the Hox genes, which are needed for the development of all bilaterally symmetrical animals. These genes are curious, as they are grouped into clusters (of which there are four in higher vertebrates) on chromosomes, and are lined up in these clusters in the same order as they are temporally and spatially expressed during development1, 2.
- Rolf Zeller is in the Department of Developmental Biology, Utrecht University, Padualaan 8, NL-3584CH Utrecht, The Netherlands.
e-mail: Email: r.zeller@bio.uu.nl - Jacqueline Deschamps is in the Hubrecht Laboratory, Uppsalalaan 8, NL-3584CT Utrecht, The Netherlands.
e-mail: Email: jacqueli@niob.knaw.nl
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