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Brief Communications

Nature 419, 895-896 (31 October 2002) | doi:10.1038/419895a

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Herbicides: Feminization of male frogs in the wild

Tyrone Hayes, Kelly Haston, Mable Tsui, Anhthu Hoang, Cathryn Haeffele & Aaron Vonk

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Water-borne herbicide threatens amphibian populations in parts of the United States.

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Atrazine is the most commonly used herbicide in the United States and probably in the world1. Here we investigate the effects of exposure to water-borne atrazine contamination on wild leopard frogs (Rana pipiens) in different regions of the United States and find that 10–92% of males show gonadal abnormalities such as retarded development and hermaphroditism. These results are supported by laboratory observations, which together highlight concerns over the biological effects of environmental atrazine on amphibians.