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Nature 419, 798-799 (24 October 2002) | doi:10.1038/419798a
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Circadian rhythms: Finer clock control
J. D. Alvarez1 & Amita Sehgal2
Abstract
The clock that governs circadian rhythms is based on a molecular feedback loop, which has just become more complex — two more proteins have been identified as likely components of the loop.
During the 1990s, chronobiologists developed a unified model of the molecular mechanisms that underlie the circadian clock in all organisms. A typical molecular clock consists of an oscillatory feedback loop generated by a few central clock genes.
- J. D. Alvarez is in the Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 6 Founders, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA.
- Amita Sehgal is at the Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, 232 Stemmler Hall, Philadelphia, Pennsylvania 19104, USA.
Correspondence to: e-mail: Email: alvarezj@mail.med.upenn.edu; Email: amita@mail.med.upenn.edu
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