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Nature 419, 790-791 (24 October 2002) | doi:10.1038/419790a
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Assistant Professor of Medicine
- Massachusetts General Hospital
- Boston, MA
Chemical Process Engineer
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
Cell biology: Survival in three dimensions
Kenneth M. Yamada & Katherine Clark
Abstract
Whether a cell lives or dies depends on various local cues. New work reveals that those cues include a cell's spatial relationship with its neighbours and polarized interactions with the adjacent extracellular matrix.
Successful cancer treatment requires both the efficient killing of tumour cells and the survival of normal cells. Because cancer chemotherapy involves drug-induced apoptosis (programmed cell death)1, a crucial question is what actually determines susceptibility to this process or protection from it.
- Kenneth M. Yamada and Katherine Clark are at the National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland 20892-4370, USA.
Correspondence to: e-mail: Email: kenneth.yamada@nih.gov; Email: katherine.clark@nih.gov
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