Table of contents


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Naturejobs

Prospects

A youthful field p3

Paul Smaglik

doi:10.1038/nj6908-03a


POSTDOCS

Does travel broaden the scientific mind? p5

Karen Kreeger

doi:10.1038/nj6908-05a


movers

Pharmaceuticals, Proteomics, Astrobiology, Drug discovery, Transitions p99

doi:10.1038/nj6908-99a


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Opinion

Do we still need astronauts? p653

Sending people into space for science is questionable and expensive. But a new proposed location for space telescopes, and the inevitable maintenance missions they will require, could provide a boost for the astronaut programme.

doi:10.1038/419653a


Towards a European Research Council p653

A meeting last week showed that Europe's science ministers should now focus on the bigger picture.

doi:10.1038/419653b


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News

Superweed study falters as seed firms deny access to transgene p655

Rex Dalton and San Diego

doi:10.1038/419655a


Ecological footprint forecasts face sceptical challenge p656

Natasha McDowell

doi:10.1038/419656a


Greenhouse gas that preserves ozone puts protocols at odds p656

Quirin Schiermeier

doi:10.1038/419656b


Japan's innovators take patent deals to court p657

David Cyranoski

doi:10.1038/419657a


Words but no cash for US agencies p657

Geoff Brumfiel

doi:10.1038/419657b


Top London colleges consider merger to form research giant p658

David Adam

doi:10.1038/419658a


Brain implants show promise against obsessive disorder p658

Alison Abbott

doi:10.1038/419658b


Structured approach bags chemistry prize p659

David Adam

doi:10.1038/419659a


Economists honoured for experimental angle p659

Rory Howlett

doi:10.1038/419659b


news in brief p660

doi:10.1038/419660a


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news feature

Fisheries science: How many more fish in the sea? p662

Commercial fisheries worldwide are being driven to collapse. Quirin Schiermeier wonders why fisheries scientists are failing to halt this pillage, and asks what hope is there for the future sustainability of fish stocks.

Quirin Schiermeier

doi:10.1038/419662a


Human spaceflight: A million-mile service p666

NASA wants many of its space telescopes to orbit far from Earth. So how will they be repaired if they go wrong? Tony Reichhardt investigates.

Tony Reichhardt

doi:10.1038/419666a


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Correspondence

Corporate ethic is now undermining universities too p667

Adoption of money-centred business practices leaves academia open to same abuses.

Raymond Pierotti

doi:10.1038/419667a


Indian biotech sets a constitutional challenge p667

Bhagirath Choudhary

doi:10.1038/419667b


All shipshape at navy lab p667

R. A. LeFande

doi:10.1038/419667c


Top

Book Reviews

The birth of molecular biology p669

How biophysicists and biochemists in the 1950s shaped a new science.

Vernon M. Ingram reviews Designs for Life: Molecular Biology After World War II by Soraya de Chadarevian

doi:10.1038/419669a


Peering through the smoke p670

Raphael Mechoulam reviews Understanding Marijuana: A New Look at Scientific Evidence by Mitch Earleywine

doi:10.1038/419670a


A protean overview p671

Robert W. Cahn reviews The Physics of Phase Transitions: Concepts and Applications by P. Papon, J. Leblond and P. H. E. Meijer

doi:10.1038/419671a


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concepts

Discounting: An eye on the future p673

Lawrence H. Goulder and Robert N. Stavins

doi:10.1038/419673a


Top

News and Views

Astronomy: Into the heart of darkness p675

The Milky Way, like other galaxies, is thought to harbour a black hole at its centre. The remarkable observation of a star in close orbit around the Galactic Centre is the first firm evidence that this is so.

Karl Gebhardt

doi:10.1038/419675a


Microbiology: All in the packaging p676

Certain bacteria generate highly toxic intermediates as part of their metabolism. Membranes with an unprecedented lipid composition and structure apparently meet the need for containment.

Edward F. DeLong

doi:10.1038/419676a


Evolution: The good, the bad and the lonely p677

In game theory, 'loners' who choose not to participate in fact promote cooperation between players. The dynamics of the game show phase transitions and complex phenomena reminiscent of statistical physics.

Franziska Michor and Martin A. Nowak

doi:10.1038/419677a


Immunology: Catch us if you can p679

Tumours have ways of evading the body's immune system. A surprising example involves a mechanism that at first sight would seem to have the opposite effect and improve immune responsiveness.

Wayne M. Yokoyama

doi:10.1038/419679a


Materials chemistry: Liquid crystals stack up p681

Take a spherical carbon 'buckyball', feather it with rod-like molecules, and the result is a distinctive shuttlecock shape that can easily be stacked into columns. Liquid-crystal phases thus formed should have unusual properties.

Carsten Tschierske

doi:10.1038/419681a


Neurobiology: Neurotrophin channels excitement p683

Sodium-ion channels usually open in response to a voltage change across the membrane in which they sit. But, surprisingly, a growth factor secreted by neurons also rapidly triggers the opening of a specific sodium channel.

Yves-Alain Barde

doi:10.1038/419683a


100 and 50 years ago p684

doi:10.1038/419684a


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Brief Communications

Plant biochemistry: An onion enzyme that makes the eyes water p685

A flavoursome, user-friendly bulb would give no cause for tears when chopped up.

S. Imai, N. Tsuge, M. Tomotake, Y. Nagatome, H. Sawada, T. Nagata and H. Kumagai

doi:10.1038/419685a


Physiology (communication arising): The ventilatory response to hypoxia p686

Philip J. Berger, Elizabeth M. Skuza, Vojta Brodecky and Malcolm H. Wilkinson

doi:10.1038/419686a


Physiology (communication arising): The ventilatory response to hypoxia p686

D. Gozal, B. M. Gaston, A. J. Lipton, M. A. Johnson, T. Macdonald and M. W. Lieberman

doi:10.1038/419686b


Top

Article

Neurotrophin-evoked depolarization requires the sodium channel NaV1.9 p687

Robert Blum, Karl W. Kafitz and Arthur Konnerth

doi:10.1038/nature01085

See also: News and Views by Barde


Top

Letters to Nature

A star in a 15.2-year orbit around the supermassive black hole at the centre of the Milky Way p694

R. Schödel, T. Ott, R. Genzel, R. Hofmann, M. Lehnert, A. Eckart, N. Mouawad, T. Alexander, M. J. Reid, R. Lenzen, M. Hartung, F. Lacombe, D. Rouan, E. Gendron, G. Rousset, A.-M. Lagrange, W. Brandner, N. Ageorges, C. Lidman, A. F. M. Moorwood, J. Spyromilio, N. Hubin and K. M. Menten

doi:10.1038/nature01121

See also: News and Views by Gebhardt


Simulation of the atmospheric thermal circulation of a martian volcano using a mesoscale numerical model p697

Scot C. R. Rafkin, Magdalena R. V. Sta. Maria and Timothy I. Michaels

doi:10.1038/nature01114


Cavity solitons as pixels in semiconductor microcavities p699

Stephane Barland, Jorge R. Tredicce, Massimo Brambilla, Luigi A. Lugiato, Salvador Balle, Massimo Giudici, Tommaso Maggipinto, Lorenzo Spinelli, Giovanna Tissoni, Thomas Knödl, Michael Miller and Roland Jäger

doi:10.1038/nature01049


Stacking of conical molecules with a fullerene apex into polar columns in crystals and liquid crystals p702

Masaya Sawamura, Kenji Kawai, Yutaka Matsuo, Kiyoshi Kanie, Takashi Kato and Eiichi Nakamura

doi:10.1038/nature01110

See also: News and Views by Tschierske


Re–Os isotopic evidence for long-lived heterogeneity and equilibration processes in the Earth's upper mantle p705

Anders Meibom, Norman H. Sleep, C. Page Chamberlain, Robert G. Coleman, Robert Frei, Michael T. Hren and Joseph L. Wooden

doi:10.1038/nature01067


Linearly concatenated cyclobutane lipids form a dense bacterial membrane p708

Jaap S. Sinninghe Damsté, Marc Strous, W. Irene C. Rijpstra, Ellen C. Hopmans, Jan A. J. Geenevasen, Adri C. T. van Duin, Laura A. van Niftrik and Mike S. M. Jetten

doi:10.1038/nature01128

See also: News and Views by DeLong


Jasmonate and salicylate induce expression of herbivore cytochrome P450 genes p712

Xianchun Li, Mary A. Schuler and May R. Berenbaum

doi:10.1038/nature01003


A biological role for prokaryotic ClC chloride channels p715

Ramkumar Iyer, Tina M. Iverson, Alessio Accardi and Christopher Miller

doi:10.1038/nature01000


Competence to replicate in the unfertilized egg is conferred by Cdc6 during meiotic maturation p718

Jean-Marc Lemaître, Stéphane Bocquet and Marcel Méchali

doi:10.1038/nature01046


Cdc6 synthesis regulates replication competence in Xenopus oocytes p722

Elizabeth Whitmire, Bettina Khan and Martine Coué

doi:10.1038/nature01032


The DIX domain targets dishevelled to actin stress fibres and vesicular membranes p726

Daniel G. S. Capelluto, Tatiana G. Kutateladze, Raymond Habas, Carla V. Finkielstein, Xi He and Michael Overduin

doi:10.1038/nature01056


Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage p729

Joan Seoane, Hong-Van Le and Joan Massagué

doi:10.1038/nature01119


Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation p734

Veronika Groh, Jennifer Wu, Cassian Yee and Thomas Spies

doi:10.1038/nature01112

See also: News and Views by Yokoyama


A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis p738

Lawryn H. Kasper, Fayçal Boussouar, Paul A. Ney, Carl W. Jackson, Jerold Rehg, Jan M. van Deursen and Paul K. Brindle

doi:10.1038/nature01062


Probing the free-energy surface for protein folding with single-molecule fluorescence spectroscopy p743

Benjamin Schuler, Everett A. Lipman and William A. Eaton

doi:10.1038/nature01060


Top

New on the Market

Genes and screens p748

Biotechnology-related products take centre stage.

doi:10.1038/419748a


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Technology Features

Bioinformatics: Bringing it all together technology feature p751

Marina Chicurel

doi:10.1038/419751a


Genome analysis at your fingertips p751

Marina Chicurel

doi:10.1038/419751b


Putting a name on it p755

Marina Chicurel

doi:10.1038/419755a


table of suppliers p759


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