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Nature 419, 679-680 (17 October 2002) | doi:10.1038/419679a
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Immunology: Catch us if you can
Wayne M. Yokoyama
Abstract
Tumours have ways of evading the body's immune system. A surprising example involves a mechanism that at first sight would seem to have the opposite effect and improve immune responsiveness.
How can tumours develop when the immune system should instead attack and destroy them? Especially difficult to understand is the situation in which tumour cells display surface molecules that should identify them as abnormal, and so should specifically activate immune cells.
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