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Nature 419, 583-587 (10 October 2002) | doi:10.1038/nature01079;
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Canada Research Chair (Tier 1) Alfred Bader Chair in Organic Chemistry
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Somatic cell nuclear transfer
Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.
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