Table of contents
Volume 419 Number 6907 pp3-652
Naturejobs
ProspectsAlternative roads to success p3
Paul Smaglik
doi:10.1038/nj6907-03a
Special Report
Plant biology goes public p4
While industrial agrobiotech R&D falters, opportunities in plant biology in the public sector are growing, says Virginia Gewin.
Virginia Gewin
doi:10.1038/nj6907-04a
Opinion
Materials for sustainability p543
Whether in energy generation or environmental protection, materials research has already made many contributions. But the community has further to go to reduce the impacts of entire cycles of materials use.
doi:10.1038/419543a
News
Regulators split on gene therapy as patient shows signs of cancer p545
Erika Check
doi:10.1038/419545a
China ponders joining fusion project p545
Geoff Brumfiel
doi:10.1038/419545b
Discovery of giant asteroid gives Pluto a rocky outlook p546
Tony Reichhardt
doi:10.1038/419546a
Call for clinical-trial reform leaves critics unmoved p546
Kendall Powell
doi:10.1038/419546b
Swiss law imposes iron rule on biotechnology field trials p547
Quirin Schiermeier
doi:10.1038/419547a
Winning universities set out to fulfil Japan's plans for excellence p547
David Cyranoski
doi:10.1038/419547b
Worm cast in starring role for Nobel prize p548
Erika Check
doi:10.1038/419548a
Universal view nets award for cosmic sleuths p548
Philip Ball
doi:10.1038/419548b
Bubble won't burst for spoof Nobels p549
Steve Nadis
doi:10.1038/419549a
news feature
Nanotechnology: Wired for success p553
Nanowires, nanorods or nanowhiskers. It doesn't matter what you call them, they're the hottest property in nanotechnology. David Appell investigates.
David Appell
doi:10.1038/419553a
New Alexandria Library: A temple of knowledge p556
The Library of Alexandria was the ancient world's premier seat of learning — its eventual destruction an intellectual tragedy. Can its spirit be revived in modern-day Egypt? Alison Abbott visits the Bibliotheca Alexandrina.
Alison Abbott
doi:10.1038/419556a
Correspondence
Taxonomy needs evolution, not revolution p559
Some changes are clearly necessary, but science cannot be replaced by informatics.
S. Knapp, R. M. Bateman, N. R. Chalmers, C. J. Humphries, P. S. Rainbow, A. B. Smith, P. D. Taylor, R. I. Vane-Wright and M. Wilkinson
doi:10.1038/419559a
Metastasis: the role of chance in malignancy p559
Paul A. W. Edwards
doi:10.1038/419559b
Metastasis: objections to the same-gene model p560
James L. Sherley
doi:10.1038/419560a
Metastasis: objections to the same-gene model p560
René Bernards and Robert A. Weinberg
doi:10.1038/419560b
Chilean decree will save nights for star-gazers p560
Maxine Singer, Augustus Oemler and Mark Phillips
doi:10.1038/419560c
Book Reviews
Move over Darwin p561
A look at the co-discoverer of natural selection. Neo-Wallaceism anyone?
James Mallet reviews In Darwin's Shadow: The Life and Science of Alfred Russel Wallace by Michael Shermer
doi:10.1038/419561a
Survival of the fishes p561
doi:10.1038/419561b
Mapping biodiversity p562
Kevin J. Gaston reviews World Atlas of Biodiversity: Earth's Living Resources in the 21st Century by Brian Groombridge and Martin D. Jenkins
doi:10.1038/419562a
Mathematics off the main line p563
John O'Connor reviews Mathematics Elsewhere: An Exploration of Ideas Across Cultures by Marcia Ascher
doi:10.1038/419563a
News and Views
Archaeology: Life with the artificial Anasazi p567
How can the complex dynamics of human societies — such as population rise and fall, and movement — be explained? Combining masses of data with computer modelling is a fresh way forward.
Jared M. Diamond
doi:10.1038/419567a
100 and 50 years ago p568
doi:10.1038/419568a
Superconductivity: Putting the squeeze on lithium p569
At low temperature, some elements are superconductors under normal pressure. Others become superconducting if the pressure is raised. Lithium is the latest low-temperature, high-pressure superconductor.
N. W. Ashcroft
doi:10.1038/419569a
Behavioural ecology: Excuses for avian infidelity p571
Arie J. van Noordwijk
doi:10.1038/419571a
Cancer: The silence of the genes p572
The discovery that a transcriptional repressor is turned on in prostate tumours as they become metastatic, leading to the silencing of many genes, suggests a new mechanism for tumour progression.
Bruce R. Zetter and Jacqueline Banyard
doi:10.1038/419572a
Nanotechnology: Beyond the silicon roadmap p573
Silicon will eventually fail to satisfy the 'smaller, faster, cheaper' drive in technology. Nanoscale techniques could take over, and a recent conference reviewed the prospects for computing and electronics.
Neil Mathur
doi:10.1038/419573a
Ecology: Biodiversity in the scales p575
Scaling coefficients can reveal nonlinear relationships among biological variables. The approach has now proved fruitful in exploring the relationship between diversity at different taxonomic levels.
Nicholas J. Gotelli
doi:10.1038/419575a
Fluid mechanics: Impact factors p576
Alison Wright
doi:10.1038/419576a
Quantum physics: Single photons stick together p577
In the right circumstances, two photons can meet and 'coalesce'. This effect has now been observed for photons emitted independently from a single-photon source, and has implications for quantum computing.
Philippe Grangier
doi:10.1038/419577a
Obituary: George Porter (1920–2002) p578
Innovator in ultrafast chemistry and advocate for pure research.
David Phillips
doi:10.1038/419578a
Brief Communications
Mechanics: Buckling cascades in free sheets p579
Wavy leaves may not depend only on their genes to make their edges crinkle.
Eran Sharon, Benoît Roman, Michael Marder, Gyu-Seung Shin and Harry L. Swinney
doi:10.1038/419579a
First paragraph | Full Text | PDF (92K)
Thin films: Wrinkling of an elastic sheet under tension p579
E. Cerda, K. Ravi-Chandar and L. Mahadevan
doi:10.1038/419579b
First paragraph | Full Text | PDF (92K)
Anthropogenic aerosols: Indirect warming effect from dispersion forcing p580
Yangang Liu and Peter H. Daum
doi:10.1038/419580a
First paragraph | Full Text | PDF (71K)
Palaeoanthropology (communication arising): Sahelanthropus or 'Sahelpithecus'? p581
Milford H. Wolpoff, Brigitte Senut, Martin Pickford and John Hawks
doi:10.1038/419581a
First paragraph | Full Text | PDF (58K)
Palaeoanthropology (communication arising): Sahelanthropus or 'Sahelpithecus'? p582
Michel Brunet, (for the authors)
doi:10.1038/419582a
First paragraph | Full Text | PDF (38K)
Progress
Somatic cell nuclear transfer p583
I. Wilmut, N. Beaujean, P. A. de Sousa, A. Dinnyes, T. J. King, L. A. Paterson, D. N. Wells and L. E. Young
doi:10.1038/nature01079
Abstract | Full Text | PDF (103K)
Article
Crystal structure of bacterial multidrug efflux transporter AcrB p587
Satoshi Murakami, Ryosuke Nakashima, Eiki Yamashita and Akihito Yamaguchi
doi:10.1038/nature01050
Abstract | Full Text | PDF (629K) | Supplementary information
Letters to Nature
Indistinguishable photons from a single-photon device p594
Charles Santori,
David Fattal,
Jelena Vu
kovi
,
Glenn S. Solomon
and
Yoshihisa Yamamoto
doi:10.1038/nature01086
First paragraph | Full Text | PDF (273K)
See also: News and Views by Grangier
Superconductivity in compressed lithium at 20 K p597
Katsuya Shimizu, Hiroto Ishikawa, Daigoroh Takao, Takehiko Yagi and Kiichi Amaya
doi:10.1038/nature01098
First paragraph | Full Text | PDF (281K)
See also: News and Views by Ashcroft
Propagation of the polyamorphic transition of ice and the liquid–liquid critical point p599
Osamu Mishima and Yoshiharu Suzuki
doi:10.1038/nature01106
First paragraph | Full Text | PDF (495K)
Directly measured mid-depth circulation in the northeastern North Atlantic Ocean p603
A. S. Bower, B. Le Cann, T. Rossby, W. Zenk, J. Gould, K. Speer, P. L. Richardson, M. D. Prater and H.-M. Zhang
doi:10.1038/nature01078
First paragraph | Full Text | PDF (2,292K)
A correlation between mid-ocean-ridge basalt chemistry and distance to continents p607
Eric Humler and Jean Besse
doi:10.1038/nature01052
First paragraph | Full Text | PDF (311K) | Supplementary information
General patterns of taxonomic and biomass partitioning in extant and fossil plant communities p610
Brian J. Enquist, John P. Haskell and Bruce H. Tiffney
doi:10.1038/nature01069
First paragraph | Full Text | PDF (1,121K) | Supplementary information
See also: News and Views by Gotelli
Genetic similarity between mates and extra-pair parentage in three species of shorebirds p613
Donald Blomqvist, Malte Andersson, Clemens Küpper, Innes C. Cuthill, János Kis, Richard B. Lanctot, Brett K. Sandercock, Tamás Székely, Johan Wallander and Bart Kempenaers
doi:10.1038/nature01104
First paragraph | Full Text | PDF (136K)
See also: News and Views by van Noordwijk
Attentional modulation in visual cortex depends on task timing p616
Geoffrey M. Ghose and John H. R. Maunsell
doi:10.1038/nature01057
First paragraph | Full Text | PDF (525K)
FGFR-related gene nou-darake restricts brain tissues to the head region of planarians p620
Francesc Cebrià, Chiyoko Kobayashi, Yoshihiko Umesono, Masumi Nakazawa, Katsuhiko Mineta, Kazuho Ikeo, Takashi Gojobori, Mari Itoh, Masanori Taira, Alejandro Sánchez Alvarado and Kiyokazu Agata
doi:10.1038/nature01042
First paragraph | Full Text | PDF (931K) | Supplementary information
The polycomb group protein EZH2 is involved in progression of prostate cancer p624
Sooryanarayana Varambally, Saravana M. Dhanasekaran, Ming Zhou, Terrence R. Barrette, Chandan Kumar-Sinha, Martin G. Sanda, Debashis Ghosh, Kenneth J. Pienta, Richard G. A. B. Sewalt, Arie P. Otte, Mark A. Rubin and Arul M. Chinnaiyan
doi:10.1038/nature01075
First paragraph | Full Text | PDF (625K) | Supplementary information
See also: News and Views by Zetter & Banyard
Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2 p629
Atsushi Kumanogoh, Satoko Marukawa, Kazuhiro Suzuki, Noriko Takegahara, Chie Watanabe, EweSeng Ch'ng, Isao Ishida, Harutoshi Fujimura, Saburo Sakoda, Kanji Yoshida and Hitoshi Kikutani
doi:10.1038/nature01037
First paragraph | Full Text | PDF (592K) | Supplementary information
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome p634
Vanessa S. Marsden, Liam O'Connor, Lorraine A. O'Reilly, John Silke, Donald Metcalf, Paul G. Ekert, David C. S. Huang, Francesco Cecconi, Keisuke Kuida, Kevin J. Tomaselli, Sophie Roy, Don W. Nicholson, David L. Vaux, Philippe Bouillet, Jerry M. Adams and Andreas Strasser
doi:10.1038/nature01101
First paragraph | Full Text | PDF (376K) | Supplementary information
Initiation and re-initiation of DNA unwinding by the Escherichia coli Rep helicase p638
Taekjip Ha, Ivan Rasnik, Wei Cheng, Hazen P. Babcock, George H. Gauss, Timothy M. Lohman and Steven Chu
doi:10.1038/nature01083
First paragraph | Full Text | PDF (228K) | Supplementary information
SATB1 targets chromatin remodelling to regulate genes over long distances p641
Dag Yasui, Masaru Miyano, Shutao Cai, Patrick Varga-Weisz and Terumi Kohwi-Shigematsu
doi:10.1038/nature01084
First paragraph | Full Text | PDF (323K)
Reaction path of protein farnesyltransferase at atomic resolution p645
Stephen B. Long, Patrick J. Casey and Lorena S. Beese
doi:10.1038/nature00986
First paragraph | Full Text | PDF (484K) | Supplementary information
New on the Market
Array for proteins, array for DNA p651
Microarrays, DNA libraries and sequencing — and siRNAs join the fray.
doi:10.1038/419651a