Access

Progress

Nature 419, 583-587 (10 October 2002) | doi:10.1038/nature01079

Open Innovation Challenges

naturejobs

Somatic cell nuclear transfer

I. Wilmut1, N. Beaujean1, P. A. de Sousa1, A. Dinnyes1,2, T. J. King1, L. A. Paterson1, D. N. Wells3 & L. E. Young1,2

Top

Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.