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Correspondence
Nature 419, 560 (10 October 2002) | doi:10.1038/419560b
Metastasis: objections to the same-gene model
René Bernards1 & Robert A. Weinberg2
- Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands
- Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
We appreciate the interest that our Concepts essay (Nature 418, 823; 2002) has evoked. But Edwards misrepresents our thinking when he writes: "If there is little difference between a primary malignant tumour and its metastases, the crucial issue becomes: what makes a tumour malignant (capable of metastasis)?
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