Table of contents
Volume 419 Number 6906 pp3-542
Naturejobs
ProspectsCareer prospects in Europe p3
Paul Smaglik
doi:10.1038/nj6906-03a
Special Report
Malaria research tools up for the future p4
Will the malaria genome open the door to new drugs, vaccines and job opportunities? Di Gershon investigates
Diane Gershon
doi:10.1038/nj6906-04a
Opinion
Reflections on scientific fraud p417
An exhaustive investigation has revealed significant contamination of the physics literature by a researcher. Such incidents are difficult to prevent, but all involved can try harder.
doi:10.1038/419417a
Time to eradicate malaria p417
The fight against the disease needs not only money but also coherence.
doi:10.1038/419417b
News
Misconduct finding at Bell Labs shakes physics community p419
Geoff Brumfiel
doi:10.1038/419419a
Keeping up appearances p419
Geoff Brumfiel
doi:10.1038/419419b
Rising star crashes back to Earth p420
Alison Abbott
doi:10.1038/419420a
Saddam gives viewers double vision p421
Quirin Schiermeier
doi:10.1038/419421a
Former ImClone chief faces allegations of past misdeeds p421
Jonathan Knight
doi:10.1038/419421b
Weak leadership threatens anti-malaria drive p422
Declan Butler
doi:10.1038/419422a
Criminal courts 'should take genetics into account' p422
David Adam
doi:10.1038/419422b
Residents force review of biodefence lab p423
Rex Dalton
doi:10.1038/419423a
Traditional owners 'should be paid' p423
Quirin Schiermeier
doi:10.1038/419423b
news feature
What difference does a genome make? p426
The malaria parasite's genome should provide a wealth of new scientific opportunities. But this may heighten tensions over how best to spend the scant resources allocated to malaria research and control. Declan Butler reports.
Declan Butler
doi:10.1038/419426a
Mosquitoes minus malaria p429
If wild populations of the mosquito that transmits malaria were replaced with insects rendered harmless by genetic engineering, the disease could finally be defeated. But that remains a big 'if', as Tom Clarke finds out.
Tom Clarke
doi:10.1038/419429a
Correspondence
Integrated programme is key to malaria control p431
Genome publication must not divert attention from basic science and public-health goals.
Jürg Utzinger, Marcel Tanner, Daniel M. Kammen, Gerry F. Killeen and Burton H. Singer
doi:10.1038/419431a
How serendipity led to an early treatment p431
Pedro Cintas
doi:10.1038/419431b
Book Reviews
Better safe than sorry p433
Is the precautionary principle a useful guide to action?
Roger Pielke, Jr reviews The Precautionary Principle in the 20th Century: Late Lessons from Early Warnings
doi:10.1038/419433a
Mind over matter? p434
Gautam R. Desiraju reviews The Ingredients: A Guided Tour of the Elements by Philip Ball
doi:10.1038/419434a
Shaking the tree of life p435
Sean Nee reviews The Nature of Diversity: An Evolutionary Voyage of Discovery by Daniel R. Brooks and Deborah A. McLennan
doi:10.1038/419435a
A splash of colour p435
doi:10.1038/419435b
News and Views
Particle physics: Cold antihydrogen p439
The production of antihydrogen, the antimatter equivalent of the hydrogen atom, at low temperatures is an impressive feat. It also raises the possibility of searching for fundamental differences between matter and antimatter.
Tom W. Hijmans
doi:10.1038/419439a
Evolutionary biology: Death in the slow lane p440
Were the Late Pleistocene extinctions of large mammals the result of climate change or big-game hunting by humans? Reconstructing the biology of extinct species provides clues to the answer.
Marcel Cardillo and Adrian Lister
doi:10.1038/419440a
100 and 50 years ago p441
doi:10.1038/419441a
Immunology: Survival of the fitters p443
Our immune system's ability to fight viruses inside our cells relies on viral protein fragments being displayed on the cell surface. The enzyme needed for the last step in this presentation process has now been discovered.
Hans-Georg Rammensee
doi:10.1038/419443a
Earth science: Lava without the fizz p445
The carbon dioxide content of lavas influences both the behaviour of Earth's mantle and its climate. In one particular case, the difficulties of directly measuring that content have been overcome.
Peter Michael
doi:10.1038/419445a
Art: Imagine space p446
Alison Wright
doi:10.1038/419446a
Brief Communications
Fish populations: When the American sea sturgeon swam east p447
A colder Baltic Sea greeted this fish from across the Atantic Ocean in the Middle Ages.
Arne Ludwig, Lutz Debus, Dietmar Lieckfeldt, Isaac Wirgin, Norbert Benecke, Ingo Jenneckens, Patrick Williot, John R. Waldman and Christian Pitra
doi:10.1038/419447a
First paragraph | Full Text | PDF (229K) | Supplementary information
Food chemistry: Acrylamide is formed in the Maillard reaction p448
Donald S. Mottram, Bronislaw L. Wedzicha and Andrew T. Dodson
doi:10.1038/419448a
First paragraph | Full Text | PDF (105K)
Food chemistry: Acrylamide from Maillard reaction products p449
Richard H. Stadler, Imre Blank, Natalia Varga, Fabien Robert, Jörg Hau, Philippe A. Guy, Marie-Claude Robert and Sonja Riediker
doi:10.1038/419449a
First paragraph | Full Text | PDF (123K)
Quantum cryptography: A step towards global key distribution p450
C. Kurtsiefer, P. Zarda, M. Halder, H. Weinfurter, P. M. Gorman, P. R. Tapster and J. G. Rarity
doi:10.1038/419450a
First paragraph | Full Text | PDF (103K)
erratum p450
doi:10.1038/419450b
Article
Vapour undersaturation in primitive mid-ocean-ridge basalt and the volatile content of Earth's upper mantle p451
Alberto E. Saal, Erik H. Hauri, Charles H. Langmuir and Michael R. Perfit
doi:10.1038/nature01073
Abstract | Full Text | PDF (564K) | Supplementary information
See also: News and Views by Michael
Letters to Nature
Production and detection of cold antihydrogen atoms p456
M. Amoretti, C. Amsler, G. Bonomi, A. Bouchta, P. Bowe, C. Carraro, C. L. Cesar, M. Charlton, M. J. T. Collier, M. Doser, V. Filippini, K. S. Fine, A. Fontana, M. C. Fujiwara, R. Funakoshi, P. Genova, J. S. Hangst, R. S. Hayano, M. H. Holzscheiter, L. V. Jørgensen, V. Lagomarsino, R. Landua, D. Lindelöf, E. Lodi Rizzini, M. Macrì, N. Madsen, G. Manuzio, M. Marchesotti, P. Montagna, H. Pruys, C. Regenfus, P. Riedler, J. Rochet, A. Rotondi, G. Rouleau, G. Testera, A. Variola, T. L. Watson and D. P. van der Werf
doi:10.1038/nature01096
First paragraph | Full Text | PDF (304K)
See also: News and Views by Hijmans
Quantum phase transition in a common metal p459
A. Yeh, Yeong-Ah Soh, J. Brooke, G. Aeppli, T. F. Rosenbaum and S. M. Hayden
doi:10.1038/nature01044
First paragraph | Full Text | PDF (375K)
Light-induced conversion of an insulating refractory oxide into a persistent electronic conductor p462
Katsuro Hayashi, Satoru Matsuishi, Toshio Kamiya, Masahiro Hirano and Hideo Hosono
doi:10.1038/nature01053
First paragraph | Full Text | PDF (502K)
Switch of flow direction in an Antarctic ice stream p465
H. Conway, G. Catania, C. F. Raymond, A. M. Gades, T. A. Scambos and H. Engelhardt
doi:10.1038/nature01081
First paragraph | Full Text | PDF (541K)
Lateralization of magnetic compass orientation in a migratory bird p467
Wolfgang Wiltschko, Joachim Traudt, Onur Güntürkün, Helmut Prior and Roswitha Wiltschko
doi:10.1038/nature00958
First paragraph | Full Text | PDF (265K)
Moving visual stimuli rapidly induce direction sensitivity of developing tectal neurons p470
Florian Engert, Huizhong W. Tao, Li I. Zhang and Mu-ming Poo
doi:10.1038/nature00988
First paragraph | Full Text | PDF (746K)
Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases p475
Wun Chey Sin, Kurt Haas, Edward S. Ruthazer and Hollis T. Cline
doi:10.1038/nature00987
First paragraph | Full Text | PDF (637K) | Supplementary information
ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum p480
Thomas Serwold, Federico Gonzalez, Jennifer Kim, Richard Jacob and Nilabh Shastri
doi:10.1038/nature01074
First paragraph | Full Text | PDF (509K)
See also: News and Views by Rammensee
Molecular basis of transmembrane signalling by sensory rhodopsin II–transducer complex p484
Valentin I. Gordeliy, Jörg Labahn, Rouslan Moukhametzianov, Rouslan Efremov, Joachim Granzin, Ramona Schlesinger, Georg Büldt, Tudor Savopol, Axel J. Scheidig, Johann P. Klare and Martin Engelhard
doi:10.1038/nature01109
First paragraph | Full Text | PDF (354K)
correction: Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum p487
Jianbing Mu, Junhui Duan, Kateryna D. Makova, Deirdre A. Joy, Chuong Q. Huynh, Oralee H. Branch, Wen-Hsiung Li and Xin-zhuan Su
doi:10.1038/nature01168
plasmodium genomics
forewordGood 'omics' for the poor? p489
Tanguy Chouard, Ursula Weiss and Ritu Dhand
doi:10.1038/419489a
commentary
The Plasmodium genome database p490
Designing and mining a eukaryotic genomics resource.
Jessica C. Kissinger, Brian P. Brunk, Jonathan Crabtree, Martin J. Fraunholz, Bindu Gajria, Arthur J. Milgram, David S. Pearson, Jonathan Schug, Amit Bahl, Sharon J. Diskin, Hagai Ginsburg, Gregory R. Grant, Dinesh Gupta, Philip Labo, Li Li, Matthew D. Mailman, Shannon K. McWeeney, Patricia Whetzel, Christian J. Stoeckert, Jr and David S. Roos
doi:10.1038/419490a
news and views
The parasite genome: The grand assault p493
The complete genome sequence of the parasite responsible for most of the world's human malaria has been determined. The nature of the genome meant that this was a difficult project, requiring considerable ingenuity.
Russell F. Doolittle
doi:10.1038/419493a
The parasite genome: Biological revelations p495
The genome of the malaria parasite was sequenced with the aim of learning more about how the parasite works, and with the hope that this would reveal potential drug targets. Has that hope been realized?
Dyann F. Wirth
doi:10.1038/419495a
The mosquito genome: The post-genomic era opens p496
The mosquito Anopheles gambiae is the main agent in the transmission of human malaria. Its genome sequence will in time help to devise control strategies, but will be a more immediate boon for insect biologists.
Ennio De Gregorio and Bruno Lemaitre
doi:10.1038/419496a
articles
Genome sequence of the human malaria parasite Plasmodium falciparum p498
Malcolm J. Gardner, Neil Hall, Eula Fung, Owen White, Matthew Berriman, Richard W. Hyman, Jane M. Carlton, Arnab Pain, Karen E. Nelson, Sharen Bowman, Ian T. Paulsen, Keith James, Jonathan A. Eisen, Kim Rutherford, Steven L. Salzberg, Alister Craig, Sue Kyes, Man-Suen Chan, Vishvanath Nene, Shamira J. Shallom, Bernard Suh, Jeremy Peterson, Sam Angiuoli, Mihaela Pertea, Jonathan Allen, Jeremy Selengut, Daniel Haft, Michael W. Mather, Akhil B. Vaidya, David M. A. Martin, Alan H. Fairlamb, Martin J. Fraunholz, David S. Roos, Stuart A. Ralph, Geoffrey I. McFadden, Leda M. Cummings, G. Mani Subramanian, Chris Mungall, J. Craig Venter, Daniel J. Carucci, Stephen L. Hoffman, Chris Newbold, Ronald W. Davis, Claire M. Fraser and Bart Barrell
doi:10.1038/nature01097
Abstract | Full Text | PDF (725K) | Supplementary information
Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii p512
Jane M. Carlton, Samuel V. Angiuoli, Bernard B. Suh, Taco W. Kooij, Mihaela Pertea, Joana C. Silva, Maria D. Ermolaeva, Jonathan E. Allen, Jeremy D. Selengut, Hean L. Koo, Jeremy D. Peterson, Mihai Pop, Daniel S. Kosack, Martin F. Shumway, Shelby L. Bidwell, Shamira J. Shallom, Susan E. van Aken, Steven B. Riedmuller, Tamara V. Feldblyum, Jennifer K. Cho, John Quackenbush, Martha Sedegah, Azadeh Shoaibi, Leda M. Cummings, Laurence Florens, John R. Yates, J. Dale Raine, Robert E. Sinden, Michael A. Harris, Deirdre A. Cunningham, Peter R. Preiser, Lawrence W. Bergman, Akhil B. Vaidya, Leo H. van Lin, Chris J. Janse, Andrew P. Waters, Hamilton O. Smith, Owen R. White, Steven L. Salzberg, J. Craig Venter, Claire M. Fraser, Stephen L. Hoffman, Malcolm J. Gardner and Daniel J. Carucci
doi:10.1038/nature01099
Abstract | Full Text | PDF (236K) | Supplementary information
A proteomic view of the Plasmodium falciparum life cycle p520
Laurence Florens, Michael P. Washburn, J. Dale Raine, Robert M. Anthony, Munira Grainger, J. David Haynes, J. Kathleen Moch, Nemone Muster, John B. Sacci, David L. Tabb, Adam A. Witney, Dirk Wolters, Yimin Wu, Malcolm J. Gardner, Anthony A. Holder, Robert E. Sinden, John R. Yates and Daniel J. Carucci
doi:10.1038/nature01107
Abstract | Full Text | PDF (484K) | Supplementary information
letters to nature
Sequence of Plasmodium falciparum chromosomes 1, 3–9 and 13 p527
N. Hall, A. Pain, M. Berriman, C. Churcher, B. Harris, D. Harris, K. Mungall, S. Bowman, R. Atkin, S. Baker, A. Barron, K. Brooks, C. O. Buckee, C. Burrows, I. Cherevach, C. Chillingworth, T. Chillingworth, Z. Christodoulou, L. Clark, R. Clark, C. Corton, A. Cronin, R. Davies, P. Davis, P. Dear, F. Dearden, J. Doggett, T. Feltwell, A. Goble, I. Goodhead, R. Gwilliam, N. Hamlin, Z. Hance, D. Harper, H. Hauser, T. Hornsby, S. Holroyd, P. Horrocks, S. Humphray, K. Jagels, K. D. James, D. Johnson, A. Kerhornou, A. Knights, B. Konfortov, S. Kyes, N. Larke, D. Lawson, N. Lennard, A. Line, M. Maddison, J. McLean, P. Mooney, S. Moule, L. Murphy, K. Oliver, D. Ormond, C. Price, M. A. Quail, E. Rabbinowitsch, M.-A. Rajandream, S. Rutter, K. M. Rutherford, M. Sanders, M. Simmonds, K. Seeger, S. Sharp, R. Smith, R. Squares, S. Squares, K. Stevens, K. Taylor, A. Tivey, L. Unwin, S. Whitehead, J. Woodward, J. E. Sulston, A. Craig, C. Newbold and B. G. Barrell
doi:10.1038/nature01095
First paragraph | Full Text | PDF (709K) | Supplementary information
Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14 p531
Malcolm J. Gardner, Shamira J. Shallom, Jane M. Carlton, Steven L. Salzberg, Vishvanath Nene, Azadeh Shoaibi, Anne Ciecko, Jeffery Lynn, Michael Rizzo, Bruce Weaver, Behnam Jarrahi, Michael Brenner, Babak Parvizi, Luke Tallon, Azita Moazzez, David Granger, Claire Fujii, Cheryl Hansen, James Pederson, Tamara Feldblyum, Jeremy Peterson, Bernard Suh, Sam Angiuoli, Mihaela Pertea, Jonathan Allen, Jeremy Selengut, Owen White, Leda M. Cummings, Hamilton O. Smith, Mark D. Adams, J. Craig Venter, Daniel J. Carucci, Stephen L. Hoffman and Claire M. Fraser
doi:10.1038/nature01094
First paragraph | Full Text | PDF (114K) | Supplementary information
Sequence of Plasmodium falciparum chromosome 12 p534
Richard W. Hyman, Eula Fung, Aaron Conway, Omar Kurdi, Jennifer Mao, Molly Miranda, Brian Nakao, Don Rowley, Tomoaki Tamaki, Fawn Wang and Ronald W. Davis
doi:10.1038/nature01102
First paragraph | Full Text | PDF (114K) | Supplementary information
Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry p537
Edwin Lasonder, Yasushi Ishihama, Jens S. Andersen, Adriaan M. W. Vermunt, Arnab Pain, Robert W. Sauerwein, Wijnand M. C. Eling, Neil Hall, Andrew P. Waters, Hendrik G. Stunnenberg and Matthias Mann
doi:10.1038/nature01111
First paragraph | Full Text | PDF (382K) | Supplementary information