Table of contents

News

'Mile-deep club' of researchers sets sights on disused gold mine p325

Geoff Brumfiel

doi:10.1038/419325a

Full Text | PDF (149K)

Polar project confirms suspicions about early Universe p325

Alison Abbott

doi:10.1038/419325b

Full Text | PDF (149K)

BSE in human tissue fires debate on patient disclosure p326

Erika Check

doi:10.1038/419326a

Full Text | PDF (84K)

Nanoscale etchings let art lovers read the small print p326

Carina Dennis

doi:10.1038/419326b

Full Text | PDF (84K)

Hostilities resume over future of GM crops p327

David Adam

doi:10.1038/419327a

Full Text | PDF (78K)

Italy's space partners left in the dark p327

Sally Goodman

doi:10.1038/419327b

Full Text | PDF (78K)

Satellite-image users fear private price hike p328

Tony Reichhardt

doi:10.1038/419328a

Full Text | PDF (135K)

Ocean geologists hatch plan to probe ancient zone p328

David Cyranoski

doi:10.1038/419328b

Full Text | PDF (135K)

NIH head looks to the 'biomedical century' p329

Erika Check

doi:10.1038/419329a

Full Text | PDF (90K)

news in brief p330

doi:10.1038/419330a

Full Text | PDF (83K)

news feature

Scientific misconduct: Sitting in judgement p332

Investigations of scientific misconduct need expert input, but they can prove harrowing experiences for the scientists involved. Erika Check finds out why.

Erika Check

doi:10.1038/419332a

Full Text | PDF (286K)

China: Stem cells rise in the East p334

As China pours research funds into regenerative medicine, its scientists are starting to explore the field's technical and ethical frontiers. Carina Dennis visits the labs that are creating an international stir.

Carina Dennis

doi:10.1038/419334a

Full Text | PDF (336K)

Correspondence

Tension arises from duality at the heart of taxonomy p337

Names must both represent a volatile hypothesis and provide a key to lasting information.

Kevin Thiele and David Yeates

doi:10.1038/419337a

No alternative to animal tests for behaviour p337

Rafael Roesler

doi:10.1038/419337b

Laws stay constant but the world changes p337

Stuart R. Gaffin

doi:10.1038/419337c

Food labels should state the benefits of GMOs p337

Renton Righelato

doi:10.1038/419337d

Book Reviews

When fish learned to walk p339

The process by which fish took to the land occurred in several steps.

Philippe Janvier reviews Gaining Ground: The Origin and Evolution of Tetrapods by Jennifer A. Clack

doi:10.1038/419339a

Full Text | PDF (127K)

Call of the wild p340

Ron Hoy reviews Signalers and Receivers: Mechanisms and Evolution of Arthropod Communication by Michael D. Greenfield

doi:10.1038/419340a

Full Text | PDF (95K)

Insects in focus p340

doi:10.1038/419340b

Full Text | PDF (95K)

Journey to the stars p341

Charles A. Wood reviews Children of the Stars: Our Origin, Evolution and Destiny by Daniel R. Altschuler and Disturbing the Solar System: Impacts, Close Encounters, and Coming Attractions by Alan E. Rubin

doi:10.1038/419341a

concepts

Cellular abstractions: Cells as computation p343

Aviv Regev and Ehud Shapiro

doi:10.1038/419343a

Full Text | PDF (118K)

News and Views

Plant-fungal interactions: When good relationships go bad p345

Mycorrhizal associations of fungi and plants are usually viewed as mutually beneficial, but some non-photosynthetic plants cheat their fungal partners. Molecular tools can now be used to identify the fungi being exploited.

David S. Hibbett

doi:10.1038/419345a

Full Text | PDF (88K)

Chemistry: Shattered mirrors p346

How did the preference for 'single-handedness' in biological molecules arise? Amplification of the trace imbalance in a mixture of handed molecules bolsters the case for chance being the answer.

Jay S. Siegel

doi:10.1038/419346a

Full Text | PDF (100K)

Membrane transport: The making of a vesicle p347

The transport of molecules from one cellular compartment to another often requires membrane-bounded carriers. New work gives insight into how the shaping of membrane into such vesicles is linked to the selection of cargo.

Anne A. Schmidt

doi:10.1038/419347a

Full Text | PDF (143K)

Virology: Ins and outs p349

Amanda Tromans

doi:10.1038/419349a

Full Text | PDF (79K)

Planetary science: Tracking the martian climate p350

Like Earth, Mars has experienced long-term fluctuations in climatic conditions. The cause of certain fluctuations is now identified as variation in the planet's astronomical behaviour.

Alan D. Howard

doi:10.1038/419350a

Full Text | PDF (359K)

Cell biology: Unchaining the condemned p351

Like prisoners, condemned intracellular proteins are shackled with chains to await their fate. These chains are a signal that the proteins must be destroyed and are removed on protein degradation. New work shows how.

Keith D. Wilkinson

doi:10.1038/419351a

Full Text | PDF (83K)

Chemistry: Material marriage in electronics p353

Self-organizing molecules can form structures with useful electronic properties. These supramolecular materials combine the benefits of polymers with those of organic crystalline systems.

E. W. Meijer and Albert P. H. J. Schenning

doi:10.1038/419353a

Full Text | PDF (89K)

correction p354

doi:10.1038/419354a

correction p354

doi:10.1038/419354b

100 and 50 years ago p354

doi:10.1038/419354c

News and Views Feature

Extrasolar planets p355

Natural philosophers have speculated on the existence of worlds around other suns for millennia. Now that real data are available, we find a diversity far beyond that expected by scientists, or science-fiction writers.

Jack J. Lissauer

doi:10.1038/419355a

Full Text | PDF (433K)

Brief Communications

Perception psychology: Visual structure of a Japanese Zen garden p359

The mysterious appeal of a simple and ancient composition of rocks is unveiled.

Gert J. Van Tonder, Michael J. Lyons and Yoshimichi Ejima

doi:10.1038/419359a

First paragraph | Full Text | PDF (187K) | Supplementary information

Fruitflies (Communication arising): Pigmentation and mate choice in Drosophila p360

Anna Llopart, Susannah Elwyn and Jerry A. Coyne

doi:10.1038/419360a

First paragraph | Full Text | PDF (37K)

Fruitflies (Communication arising): Pigmentation and mate choice in Drosophila p360

Artyom Kopp and Sean B. Carroll

doi:10.1038/419360b

First paragraph | Full Text | PDF (37K)

Articles

Curvature of clathrin-coated pits driven by epsin p361

Marijn G. J. Ford, Ian G. Mills, Brian J. Peter, Yvonne Vallis, Gerrit J. K. Praefcke, Philip R. Evans and Harvey T. McMahon

doi:10.1038/nature01020

Abstract | Full Text | PDF (1,208K) | Supplementary information

The harlequin mouse mutation downregulates apoptosis-inducing factor p367

Jeffrey A. Klein, Chantal M. Longo-Guess, Marlies P. Rossmann, Kevin L. Seburn, Ronald E. Hurd, Wayne N. Frankel, Roderick T. Bronson and Susan L. Ackerman

doi:10.1038/nature01034

Abstract | Full Text | PDF (527K) | Supplementary information

Letters to Nature

Orbital forcing of the martian polar layered deposits p375

Jacques Laskar, Benjamin Levrard and John F. Mustard

doi:10.1038/nature01066

First paragraph | Full Text | PDF (484K)

Artificial charge-modulationin atomic-scale perovskite titanate superlattices p378

A. Ohtomo, D. A. Muller, J. L. Grazul and H. Y. Hwang

doi:10.1038/nature00977

First paragraph | Full Text | PDF (337K)

Designing intermediate-range order in amorphous materials p381

James D. Martin, Stephen J. Goettler, Nathalie Fossé and Lennox Iton

doi:10.1038/nature01022

First paragraph | Full Text | PDF (237K) | Supplementary information

Self-organization of supramolecular helical dendrimers into complex electronic materials p384

V. Percec, M. Glodde, T. K. Bera, Y. Miura, I. Shiyanovskaya, K. D. Singer, V. S. K. Balagurusamy, P. A. Heiney, I. Schnell, A. Rapp, H.-W. Spiess, S. D. Hudson and H. Duan

doi:10.1038/nature01072

First paragraph | Full Text | PDF (639K) | Supplementary information

Copepod hatching success in marine ecosystems with high diatom concentrations p387

Xabier Irigoien, Roger P. Harris, Hans M. Verheye, Pierre Joly, Jeffrey Runge, Michel Starr, David Pond, Robert Campbell, Rachael Shreeve, Peter Ward, Amy N. Smith, Hans G. Dam, William Peterson, Valentina Tirelli, Marja Koski, Tania Smith, Derek Harbour and Russell Davidson

doi:10.1038/nature01055

First paragraph | Full Text | PDF (176K) | Supplementary information

Epiparasitic plants specialized on arbuscular mycorrhizal fungi p389

Martin I. Bidartondo, Dirk Redecker, Isabelle Hijri, Andres Wiemken, Thomas D. Bruns, Laura Domínguez, Alicia Sérsic, Jonathan R. Leake and David J. Read

doi:10.1038/nature01054

First paragraph | Full Text | PDF (440K)

RGM is a repulsive guidance molecule for retinal axons p392

Philippe P. Monnier, Ana Sierra, Paolo Macchi, Lutz Deitinghoff, Jens S. Andersen, Matthias Mann, Manuela Flad, Martin R. Hornberger, Bernd Stahl, Friedrich Bonhoeffer and Bernhard K. Mueller

doi:10.1038/nature01041

First paragraph | Full Text | PDF (1,124K)

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency p395

Hyung J. Chun, Lixin Zheng, Manzoor Ahmad, Jin Wang, Christina K. Speirs, Richard M. Siegel, Janet K. Dale, Jennifer Puck, Joie Davis, Craig G. Hall, Suzanne Skoda-Smith, T. Prescott Atkinson, Stephen E. Straus and Michael J. Lenardo

doi:10.1038/nature01063

First paragraph | Full Text | PDF (380K) | Supplementary information

A putative lipid transfer protein involved in systemic resistance signalling in Arabidopsis p399

Ana M. Maldonado, Peter Doerner, Richard A. Dixon, Chris J. Lamb and Robin K. Cameron

doi:10.1038/nature00962

First paragraph | Full Text | PDF (573K) | Supplementary information

A cryptic protease couples deubiquitination and degradation by the proteasome p403

Tingting Yao and Robert E. Cohen

doi:10.1038/nature01071

First paragraph | Full Text | PDF (315K) | Supplementary information

Active genes are tri-methylated at K4 of histone H3 p407

Helena Santos-Rosa, Robert Schneider, Andrew J. Bannister, Julia Sherriff, Bradley E. Bernstein, N. C. Tolga Emre, Stuart L. Schreiber, Jane Mellor and Tony Kouzarides

doi:10.1038/nature01080

First paragraph | Full Text | PDF (206K) | Supplementary information

Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair p411

Alexander W. Bird, David Y. Yu, Marilyn G. Pray-Grant, Qifeng Qiu, Kirsty E. Harmon, Paul C. Megee, Patrick A. Grant, M. Mitchell Smith and Michael F. Christman

doi:10.1038/nature01035

First paragraph | Full Text | PDF (250K) | Supplementary information