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Nature 419, 351-353 (26 September 2002) | doi:10.1038/419351a
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Biochemical Pharmacologist
- Eisai London Research Laboratories Ltd
- Hatfield, United Kingdom
Developer - Variation (Bioinformatician)
- European Bioinformatics Institute (EBI)
- Cambridge CB10 1SD United Kingdom
Cell biology: Unchaining the condemned
Keith D. Wilkinson
Abstract
Like prisoners, condemned intracellular proteins are shackled with chains to await their fate. These chains are a signal that the proteins must be destroyed and are removed on protein degradation. New work shows how.
To carry out their functions properly, the proteins in our cells must be in the right place at the right time, and at the right concentration. So it's vital that cells achieve the correct balance between protein synthesis and destruction.
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