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Review
Nature 419, 35-42 (5 September 2002) | doi:10.1038/nature00978
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Senior Scientist, Chemoinformatics
- Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
- Copenhagen 2200 Denmark
Bioresearch Manager
- Philip Morris International (PMI)
- Singapore
The voltage-gated potassium channels and their relatives
Gary Yellen
Abstract
The voltage-gated potassium channels are the prototypical members of a family of membrane signalling proteins. These protein-based machines have pores that pass millions of ions per second across the membrane with astonishing selectivity, and their gates snap open and shut in milliseconds as they sense changes in voltage or ligand concentration. The architectural modules and functional components of these sophisticated signalling molecules are becoming clear, but some important links remain to be elucidated.
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