Table of contents
Volume 418 Number 6901 pp3-1002
Opinion
Clones: oddities or businesses? p903
The woes of the biotechnology sector have been compounded by technical obstacles for companies seeking to develop cloning technologies. For benefits to materialize, scientific understanding needs fostering by industry and governments.
doi:10.1038/418903a
Nature Materials arrives p903
A new forum for diverse disciplines is launched next week.
doi:10.1038/418903b
News
Central Europe braced for tide of pollution in flood aftermath p905
Quirin Schiermeier
doi:10.1038/418905a
Web extends to bottom of the world p905
David Adam
doi:10.1038/418905b
US prepares ground for security clampdown p906
Erika Check
doi:10.1038/418906a
Oceanographer navigates path to the Smithsonian p906
Kendall Powell
doi:10.1038/418906b
Fraud inquiry leaves online paper in the ether p907
Geoff Brumfiel
doi:10.1038/418907a
Pike pests ravage Alaska's salmon p907
Rex Dalton
doi:10.1038/418907b
French agency plans biomedical reformation p908
Sally Goodman
doi:10.1038/418908a
Hologram technique to flush out features of bog body p908
Alison Abbott
doi:10.1038/418908b
news feature
Chimpanzee genome: Almost human... p910
Sequencing the chimpanzee has emerged as a top genomic priority. David Cyranoski asks the chimp's champions what they hope to gain from studying the genome of our closest living relative.
David Cyranoski
doi:10.1038/418910a
Methane hydrates: Fire from ice p913
Natural gas is in great demand, and researchers know where vast amounts are hidden — in icy crystals called hydrates. But getting it out is another matter, as David Adam finds out.
David Adam
doi:10.1038/418913a
Correspondence
Vaccines should be kept even if polio is wiped out p915
Jeronimo Cello, Aniko V. Paul and Eckard Wimmer
doi:10.1038/418915a
Arp2/3 plays no role in muscle contraction p915
Thomas D. Pollard, Dorit Hanein and Niels Volkmann
doi:10.1038/418915b
Seeing stars p915
Rob A. Gruters
doi:10.1038/418915c
Thriving UCSF needs all the space it can get p915
Regis Kelly
doi:10.1038/418915d
Efforts to revive Serbian science p915
Members of the 'old guard' remain in power and are hindering moves to change a demoralized culture.
Petar Grujic
doi:10.1038/418915e
Book Reviews
Shadows of Plato's genes p917
Regulatory gene pathways could explain animals' different morphologies.
Rudolf A. Raff reviews The Evolution of Developmental Pathways by Adam S. Wilkins
doi:10.1038/418917a
Trying to make sense of art p918
Semir Zeki reviews Vision and Art: The Biology of Seeing by Margaret Livingstone
doi:10.1038/418918a
A rounded view of Faraday p919
Jacqueline Reynolds and Charles Tanford review Faraday: The Life by James Hamilton
doi:10.1038/418919a
The temperature of everything p919
Vaclav Smil reviews A Matter of Degrees: What Temperature Reveals About the Past and Future of Our Species, Planet, and Universe by Gino Segrè
doi:10.1038/418919b
Science in culture p920
Liz Hoggard reviews
doi:10.1038/418920a
concepts
Ageing: A lethal side-effect p921
Ageing is bad for us and yet it happens to everyone. So why does it occur at all?
Linda Partridge and David Gems
doi:10.1038/418921a
News and Views
Immunology: Inside the professionals p923
Real-time microscopy is providing fresh insights in many fields of biology. Immunology is no exception, as demonstrated by striking images of the inner workings of dendritic cells.
Jonathan W. Yewdell and David C. Tscharke
doi:10.1038/418923a
Planetary science: Birth of a Solar System p924
Radioisotope dating of meteorites suggests that planets formed in the Solar System over shorter timescales than had been thought. There are consequences for how the Moon formed, but is this the final word?
A. G. W. Cameron
doi:10.1038/418924a
Marine biology: Unveiling an ocean phantom p925
Certain episodes of mass fish mortality in coastal waters off the eastern United States have been ascribed to a planktonic organism called Pfiesteria. There are now fresh clues to how these fish are killed.
Vera L. Trainer
doi:10.1038/418925a
Apoptosis: Sculpture of a fly's head p926
Hox proteins are needed during development to produce body segments with different shapes and functions. In fruitflies, one Hox protein sculpts certain segments of the head by activating a cell-death-inducing gene.
Jun R. Huh and Bruce A. Hay
doi:10.1038/418926a
100 and 50 years ago p927
doi:10.1038/418927a
Renewable fuels: Harnessing hydrogen p928
Biomass can produce clean fuels and could be a vital, renewable energy source for the future. The demonstration of hydrogen production from biomass-derived molecules marks progress towards this goal.
Esteban Chornet and Stefan Czernik
doi:10.1038/418928a
Oceanography: Crossing the highway p928
Heike Langenberg
doi:10.1038/418928b
Cognitive neuroscience: The molecules of forgetfulness p929
Not everything that we learn is useful, so the brain needs a mechanism to prevent itself being burdened by unhelpful details. The molecular details of this mechanism are now being uncovered.
Alcino J. Silva and Sheena A. Josselyn
doi:10.1038/418929a
Brief Communications
Agriculture: Widespread local house-sparrow extinctions p931
Agricultural intensification is blamed for the plummeting populations of these birds.
David G. Hole, Mark J. Whittingham, Richard B. Bradbury, Guy Q. A. Anderson, Patricia L. M. Lee, Jeremy D. Wilson and John R. Krebs
doi:10.1038/418931a
First paragraph | Full Text | PDF (52K)
Ageing: Cognitive change and the APOE 
4 allele p932
Ian J. Deary, Martha C. Whiteman, Alison Pattie, John M. Starr, Caroline Hayward, Alan F. Wright, Andrew Carothers and Lawrence J. Whalley
doi:10.1038/418932a
First paragraph | Full Text | PDF (137K)
Nuclear fusion: Fast heating scalable to laser fusion ignition p933
R. Kodama, H. Shiraga, K. Shigemori, Y. Toyama, S. Fujioka, H. Azechi, H. Fujita, H. Habara, T. Hall, Y. Izawa, T. Jitsuno, Y. Kitagawa, K. M. Krushelnick, K. L. Lancaster, K. Mima, K. Nagai, M. Nakai, H. Nishimura, T. Norimatsu, P. A. Norreys, S. Sakabe, K. A. Tanaka, A. Youssef, M. Zepf and T. Yamanaka
doi:10.1038/418933a
First paragraph | Full Text | PDF (67K)
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status p934
Harith Rajagopalan, Alberto Bardelli, Christoph Lengauer, Kenneth W. Kinzler, Bert Vogelstein and Victor E. Velculescu
doi:10.1038/418934a
First paragraph | Full Text | PDF (46K)
Review
Coordination of circadian timing in mammals p935
Steven M. Reppert and David R. Weaver
doi:10.1038/nature00965
Abstract | Full Text | PDF (457K)
Article
Open channel structure of MscL and the gating mechanism of mechanosensitive channels p942
Eduardo Perozo, D. Marien Cortes, Pornthep Sompornpisut, Anna Kloda and Boris Martinac
doi:10.1038/nature00992
Abstract | Full Text | PDF (665K) | Supplementary information
Letters to Nature
A short timescale for terrestrial planet formation from Hf–W chronometry of meteorites p949
Qingzhu Yin, S. B. Jacobsen, K. Yamashita, J. Blichert-Toft, P. Télouk and F. Albarède
doi:10.1038/nature00995
First paragraph | Full Text | PDF (241K)
See also: News and Views by Cameron
Rapid accretion and early core formation on asteroids and the terrestrial planets from Hf–W chronometry p952
T. Kleine, C. Münker, K. Mezger and H. Palme
doi:10.1038/nature00982
First paragraph | Full Text | PDF (191K)
See also: News and Views by Cameron
Metal–insulator transition in chains with correlated disorder p955
Pedro Carpena, Pedro Bernaola-Galván, Plamen Ch. Ivanov and H. Eugene Stanley
doi:10.1038/nature00948
First paragraph | Full Text | PDF (523K) | Supplementary information
Near-infrared sensitivity enhancement of photorefractive polymer composites by pre-illumination p959
Erwin Mecher, Francisco Gallego-Gómez, Hartwig Tillmann, Hans-Heinrich Hörhold, Jan C. Hummelen and Klaus Meerholz
doi:10.1038/nature00975
First paragraph | Full Text | PDF (443K)
Hydrogen from catalytic reforming of biomass-derived hydrocarbons in liquid water p964
R. D. Cortright, R. R. Davda and J. A. Dumesic
doi:10.1038/nature01009
First paragraph | Full Text | PDF (194K)
See also: News and Views by Chornet & Czernik
Pfiesteria shumwayae kills fish by micropredation not exotoxin secretion p967
Wolfgang K. Vogelbein, Vincent J. Lovko, Jeffrey D. Shields, Kimberly S. Reece, Patrice L. Mason, Leonard W. Haas and Calvin C. Walker
doi:10.1038/nature01008
First paragraph | Full Text | PDF (246K) | Supplementary information
See also: News and Views by Trainer
Protein phosphatase 1 is a molecular constraint on learning and memory p970
David Genoux, Ursula Haditsch, Marlen Knobloch, Aubin Michalon, Daniel Storm and Isabelle M. Mansuy
doi:10.1038/nature00928
First paragraph | Full Text | PDF (454K)
See also: News and Views by Silva & Josselyn
Chromosomal clustering of muscle-expressed genes in Caenorhabditis elegans p975
Peter J. Roy, Joshua M. Stuart, Jim Lund and Stuart K. Kim
doi:10.1038/nature01012
First paragraph | Full Text | PDF (448K) | Supplementary information
Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity p979
Ying Litingtung, Randall D. Dahn, Yina Li, John F. Fallon and Chin Chiang
doi:10.1038/nature01033
First paragraph | Full Text | PDF (289K) | Supplementary information
T-cell engagement of dendritic cells rapidly rearranges MHC class II transport p983
Marianne Boes, Jan Cerny, Ramiro Massol, Marjolein Op den Brouw, Tom Kirchhausen, Jianzhu Chen and Hidde L. Ploegh
doi:10.1038/nature01004
First paragraph | Full Text | PDF (532K) | Supplementary information
See also: News and Views by Yewdell & Tscharke
Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane p988
Amy Chow, Derek Toomre, Wendy Garrett and Ira Mellman
doi:10.1038/nature01006
First paragraph | Full Text | PDF (520K) | Supplementary information
See also: News and Views by Yewdell & Tscharke
A chromatin remodelling complex that loads cohesin onto human chromosomes p994
Mohamed-Ali Hakimi, Daniel A. Bochar, John A. Schmiesing, Yuanshu Dong, Orr G. Barak, David W. Speicher, Kyoko Yokomori and Ramin Shiekhattar
doi:10.1038/nature01024
First paragraph | Full Text | PDF (513K) | Supplementary information
Reverse engineering of the giant muscle protein titin p998
Hongbin Li, Wolfgang A. Linke, Andres F. Oberhauser, Mariano Carrion-Vazquez, Jason G. Kerkvliet, Hui Lu, Piotr E. Marszalek and Julio M. Fernandez
doi:10.1038/nature00938
First paragraph | Full Text | PDF (457K) | Supplementary information