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From the following article:

Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity

Ying Litingtung, Randall D. Dahn, Yina Li, John F. Fallon and Chin Chiang

Nature 418, 979-983(29 August 2002)

doi:10.1038/nature01033

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Gli3 regulates digit number and identity.

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Figure 2

Shh signalling regulates Gli3 processing in the mouse limb.

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Figure 3

Regulation of putative SHH target genes in the limb. E10.5 wild-type, Shh-/-, Gli3-/-, Shh-/-Gli3-/- and Shh-/-Gli3+/- forelimb buds were examined for expression of Gli1, Ptch1, Hoxd12, dHand and Bmp2.

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Figure 4

Shh maintains ridge function by relieving an antagonistic regulatory cascade.

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