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Nature 418, 884-889 (22 August 2002) | doi:10.1038/nature01026;

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Open Innovation Challenges

A bacteriolytic agent that detects and kills Bacillus anthracis

The dormant and durable spore form of Bacillus anthracis is an ideal biological weapon of mass destruction. Once inhaled, spores are transported by alveolar macrophages to lymph nodes surrounding the lungs, where they germinate; subsequent vegetative expansion causes an overwhelming flood of bacteria and toxins into the blood, killing up to 99% of untreated victims.

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