Figures and Tables

From the following article:

Multiple regulatory sites in large-conductance calcium-activated potassium channels

Xiao-Ming Xia, Xuhui Zeng and Christopher J. Lingle

Nature 418, 880-884(22 August 2002)

doi:10.1038/nature00956

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Figure 1

Schematic representation of the Slo1 alpha-subunit.

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Figure 2

The Ca2+ bowl and D362A/D367A account for all physiologically relevant Ca2+-dependent regulation of BK channels.

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Figure 3

The RCK domain also mediates effects of high concentrations of Ca2+ and Mg2+.

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Figure 4

Mutation of all three regulatory elements produces Ca2+-dependent suppression of BK current.

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