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Nature 418, 734-736 (15 August 2002) | doi:10.1038/418734a
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Signal transduction: Positive feedback from coffee
Jean-Marie Vaugeois
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Abstract
Caffeine acts on our nerve cells to wake us up. It turns out that it does so through a molecular signalling pathway that involves a positive feedback loop, boosting caffeine's effects from inside the cell.
Have you ever wondered why coffee is such an effective pick-me-up? The answer has been gradually coming into focus over the past few years, thanks to numerous studies of the brain regions and neuronal molecules affected.
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