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Nature 418, 737-739 (15 August 2002) | doi:10.1038/418737a
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Professor of Experimental Virology (W3)
- University Hospital Jena, Institute of Virology and Antivirale Therapy
- Jena, Germany
John Innes Centre Project Leader in Plant or Microbial Sciences
- University of East Anglia
- Norwich, NR4 7TJ, UK
Developmental biology: Signalling legacies
Richard S. Mann1 & Fernando Casares2
Abstract
Until now, the signals that control the development of the legs in insects and vertebrates have been thought to be different. But new work reveals similarities, which might have evolutionary implications.
We live in a three-dimensional world and, not surprisingly, the development of many animals — including ourselves — depends on the establishment of three body axes. Two of these, the head-to-tail (anterior–posterior) and back-to-front (dorsal–ventral) axes, are established in the egg before fertilization or, in some cases, as an immediate result of fertilization.
- Richard S. Mann is in the Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, New York, New York 10032, USA.
e-mail: Email: rsm10@columbia.edu - Fernando Casares is at the Instituto de Biologia Molecular e Celular (IBMC), Rua do Campo Alegre 823, 4150-180 Porto, Portugal.
e-mail: Email: fcasares@ibmc.up.pt
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