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Nature 418, 598-599 (8 August 2002) | doi:10.1038/418598b
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Structural biology: Calcium callisthenics
N. Michael Green1 & David H. MacLennan2
Abstract
The Ca2+-ATPase is one of the best characterized of the pumps that move ions across cell membranes. The latest snapshot of the pump in another of its many conformations is a major step in understanding its dynamics.
The action of skeletal muscle depends on the flow of calcium ions into and out of a storage compartment — the sarcoplasmic reticulum — in muscle cells. Release of Ca2+ into the cytosol stimulates muscle contraction.
- N. Michael Green is at the National Institute of
Medical Research, Mill Hill, London NW7
1AA, UK.
e-mail: Email: mgreen@nimr.mrc.ac.uk - David H. MacLennan is in the Banting and Best
Department of Medical Research, University of Toronto,
Toronto, Ontario M5G 1L6, Canada.
e-mail: Email: david.maclennan@utoronto.ca
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