Figures and Tables

From the following article:

Structural changes in the calcium pump accompanying the dissociation of calcium

Chikashi Toyoshima & Hiromi Nomura

Nature 418, 605-611(8 August 2002)

doi:10.1038/nature00944

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Ribbon representation of SR Ca2+-ATPase in the Ca2+-bound form (E1Ca2+) and that (E2(TG)) in the absence of Ca2+ but in the presence of thapsigargin (TG).

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Figure 2

Superimposition of the Ca2+-bound form (E1Ca2+, violet) and the thapsigargin-bound form (E2(TG), light green) of Ca2+-ATPase fitted with the transmembrane domain. alpha-Helices are represented by cylinders and beta-strands by arrows.

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Figure 3

Interface between the transmembrane helices (M3–M5) and the P domain of Ca2+-ATPase.

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Figure 4

Rearrangement of transmembrane helices viewed from the rear (a), and a diagram illustrating the shift of M4 normal to the membrane by the tilting of M5 (b).

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Figure 5

Conformation changes around the Ca2+-binding sites.

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Figure 6

Thapsigargin (TG) binding site in Ca2+-ATPase.

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