Table of contents
Volume 418 Number 6897 pp3-568
Opinion
Dispatches from the front line p465
The rich world's corridors of power echo with talk about the new 'war on terrorism'. Meanwhile, most developing countries are losing another war that has already inflicted millions of casualties.
doi:10.1038/418465a
All together now... p465
Britain's chief scientific adviser wants to revamp the government's fragmented approach to science. Let's hope he succeeds.
doi:10.1038/418465b
News
Row over neutron source hots up as Germany's advisers cry foul p467
Quirin Schiermeier
doi:10.1038/418467a
Accused obesity researcher returns to the French fold p467
Declan Butler
doi:10.1038/418467b
Falling share price stymies gift to university p468
Rex Dalton
doi:10.1038/418468a
Asteroid rating system makes an impact on the media p468
Jonathan Knight
doi:10.1038/418468b
Model success is not the end of the matter p469
Geoff Brumfiel
doi:10.1038/418469a
'Superbug' hurdles key drug barrier p469
Helen Pearson
doi:10.1038/418469b
Biomedical institute suffers growing pains p470
Erika Check
doi:10.1038/418470a
Opponents of stem-cell patent win restrictions p470
Alison Abbott and Oliver Schmidt
doi:10.1038/418470b
news feature
Microfluidics: Honey, I shrunk the lab p474
Take a lab full of test tubes, flasks and stirrers, and cram it onto a silicon chip — that's the dream of microfluidics researchers. And as Jonathan Knight finds out, this vision is becoming a practical reality.
Jonathan Knight
doi:10.1038/418474a
Scientific uncertainty: When doubt is a sure thing p476
Is it possible to adopt a more rigorous approach to the communication of scientific uncertainty? Jim Giles talks to the climatologists whose pursuit of this goal has seen them dubbed the 'uncertainty cops'.
Jim Giles
doi:10.1038/418476a
Correspondence
DNA points the way ahead in taxonomy p479
In assessing new approaches, it's time for DNA's unique contribution to take a central role.
Diethard Tautz, Peter Arctander, Alessandro Minelli, Richard H. Thomas and Alfried P. Vogler
doi:10.1038/418479a
Israeli concern about Palestinian suffering p479
Victoria Buch
doi:10.1038/418479b
Science council replies to neutron claims p479
Karl Max Einhäupl
doi:10.1038/418479c
Book Reviews
A whole new world of geology p481
The canals have faded from view, but Mars remains tantalizingly out of reach.
Greg Bear reviews Mapping Mars: Science, Imagination, and the Birth of a World by Oliver Morton
doi:10.1038/418481a
A historian of Victorian astronomy p482
Donald E. Osterbrock reviews Agnes Mary Clerke and the Rise of Astrophysics by Mary Brück
doi:10.1038/418482a
Lost languages p482
doi:10.1038/418482b
A bestial feast p483
Tim Birkhead reviews Dr Tatiana's Sex Advice to All Creation: The Definitive Guide to the Evolutionary Biology of Sex by Olivia Judson
doi:10.1038/418483a
concepts
Antibody catalysis: Completing the circle p485
The use of immunological diversity to generate selective catalysts has come full circle, to the realization that antibodies have an intrinsic catalytic ability to destroy antigens.
P. G. Schultz and R. A. Lerner
doi:10.1038/418485a
News and Views
Planetary science: Impacts in the round p487
A well-preserved crater has been identified deep beneath the bed of the North Sea. It may well have been produced by the impact of an extraterrestrial body some 60 million years ago.
John G. Spray
doi:10.1038/418487a
100 and 50 years ago p488
doi:10.1038/418488a
Neurobiology: Never fear, cannabinoids are here p488
Although we understand how fearful memories are stored in the brain, how they are extinguished remains a mystery. The answers may lie with the cannabinoid compounds our bodies produce.
Pankaj Sah
doi:10.1038/418488b
Earth science: Core values p489
Calculating the age of the Earth's solid inner core has proved to be a tricky business. But the suggestion that there is more potassium in the core than had been thought could help to reconcile differing estimates.
John Brodholt and Francis Nimmo
doi:10.1038/418489a
Materials: Zeolites branch out p491
Rosamund Daw
doi:10.1038/418491a
Developmental biology: Making progress with limb models p492
What is the developmental mechanism that makes our upper arms different from our forearms or fingers? Two new papers challenge an influential and popular model, and propose an alternative view.
Denis Duboule
doi:10.1038/418492a
Applied physics: Ultrafast magnetic switching p493
Magnetic-memory devices rely on fast switching of the magnetization vector in a material to store data. The speed of such devices could be increased by adding a magnetic-pulse-shaping technique.
Burkard Hillebrands and Jürgen Fassbender
doi:10.1038/418493a
Cell cycle: Oscillation sensation p495
Various molecular actors play out the scene in which a cell exits mitosis — nuclear division — before entering the next cell cycle. One of them, the protein Clb2, steps back into the spotlight. Another, Clb5, bows out.
David O. Morgan and James M. Roberts
doi:10.1038/418495a
Brief Communications
Oogenesis: Maturation of mouse fetal germ cells in vitro p497
Even immature oocytes can eventually be fertilized after some skilful manipulation.
Yayoi Obata, Tomohiro Kono and Izuho Hatada
doi:10.1038/418497a
First paragraph | Full Text | PDF (118K) | Supplementary information
Gene silencing: Trans-histone regulatory pathway in chromatin p498
Scott D. Briggs, Tiaojiang Xiao, Zu-Wen Sun, Jennifer A. Caldwell, Jeffrey Shabanowitz, Donald F. Hunt, C. David Allis and Brian D. Strahl
doi:10.1038/nature00970
First paragraph | Full Text | PDF (47K) | Supplementary information
Astrophysics (Communication arising): Supernova-remnant origin of cosmic rays? p499
Yousaf M. Butt, Diego F. Torres, Gustavo E. Romero, Thomas M. Dame and Jorge A. Combi
doi:10.1038/418499a
First paragraph | Full Text | PDF (87K)
Behavioural evolution (Communication arising): Does similarity breed cooperation? p499
Gilbert Roberts and Thomas N. Sherratt
doi:10.1038/418499b
First paragraph | Full Text | PDF (87K)
Behavioural evolution (Communication arising): Does similarity breed cooperation? p500
Rick L. Riolo, Michael D. Cohen and Robert Axelrod
doi:10.1038/418500a
First paragraph | Full Text | PDF (38K)
Article
Functions of FGF signalling from the apical ectodermal ridge in limb development p501
Xin Sun, Francesca V. Mariani and Gail R. Martin
doi:10.1038/nature00902
Abstract | Full Text | PDF (518K) | Supplementary information
See also: News and Views by Duboule
Letters to Nature
Ultrafast precessional magnetization reversal by picosecond magnetic field pulse shaping p509
Th. Gerrits, H. A. M. van den Berg, J. Hohlfeld, L. Bär and Th. Rasing
doi:10.1038/nature00905
First paragraph | Full Text | PDF (304K)
See also: News and Views by Hillebrands & Fassbender
Single-pulse coherently controlled nonlinear Raman spectroscopy and microscopy p512
Nirit Dudovich, Dan Oron and Yaron Silberberg
doi:10.1038/nature00933
First paragraph | Full Text | PDF (184K)
A large-cavity zeolite with wide pore windows and potential as an oil refining catalyst p514
Avelino Corma, María J. Díaz-Cabañas, Joaquín Martínez-Triguero, Fernando Rey and Jordi Rius
doi:10.1038/nature00924
First paragraph | Full Text | PDF (255K) | Supplementary information
Lamellar magnetism in the haematite–ilmenite series as an explanation for strong remanent magnetization p517
Peter Robinson, Richard J. Harrison, Suzanne A. McEnroe and Robert B. Hargraves
doi:10.1038/nature00942
First paragraph | Full Text | PDF (275K)
A 20-km-diameter multi-ringed impact structure in the North Sea p520
Simon A. Stewart and Philip J. Allen
doi:10.1038/nature00914
First paragraph | Full Text | PDF (583K)
See also: News and Views by Spray
The evolution of inaccurate mimics p524
Rufus A. Johnstone
doi:10.1038/nature00845
First paragraph | Full Text | PDF (171K)
Fractal geometry predicts varying body size scaling relationships for mammal and bird home ranges p527
John P. Haskell, Mark E. Ritchie and Han Olff
doi:10.1038/nature00840
First paragraph | Full Text | PDF (266K)
The endogenous cannabinoid system controls extinction of aversive memories p530
Giovanni Marsicano, Carsten T. Wotjak, Shahnaz C. Azad, Tiziana Bisogno, Gerhard Rammes, Maria Grazia Cascio, Heike Hermann, Jianrong Tang, Clementine Hofmann, Walter Zieglgänsberger, Vincenzo Di Marzo and Beat Lutz
doi:10.1038/nature00839
First paragraph | Full Text | PDF (362K) | Supplementary information
See also: News and Views by Sah
A transcription factor response element for gene expression during circadian night p534
Hiroki R. Ueda, Wenbin Chen, Akihito Adachi, Hisanori Wakamatsu, Satoko Hayashi, Tomohiro Takasugi, Mamoru Nagano, Ken-ichi Nakahama, Yutaka Suzuki, Sumio Sugano, Masamitsu Iino, Yasufumi Shigeyoshi and Seiichi Hashimoto
doi:10.1038/nature00906
First paragraph | Full Text | PDF (464K) | Supplementary information
A re-examination of proximodistal patterning during vertebrate limb development p539
Andrew T. Dudley, María A. Ros and Clifford J. Tabin
doi:10.1038/nature00945
First paragraph | Full Text | PDF (350K)
See also: News and Views by Duboule
A first-generation linkage disequilibrium map of human chromosome 22 p544
Elisabeth Dawson, Gonçalo R. Abecasis, Suzannah Bumpstead, Yuan Chen, Sarah Hunt, David M. Beare, Jagjit Pabial, Thomas Dibling, Emma Tinsley, Susan Kirby, David Carter, Marianna Papaspyridonos, Simon Livingstone, Rocky Ganske, Elin Lõhmussaar, Jana Zernant, Neeme Tõnisson, Maido Remm, Reedik Mägi, Tarmo Puurand, Jaak Vilo, Ants Kurg, Kate Rice, Panos Deloukas, Richard Mott, Andres Metspalu, David R. Bentley, Lon R. Cardon and Ian Dunham
doi:10.1038/nature00864
First paragraph | Full Text | PDF (659K) | Supplementary information
Golgi biogenesis in Toxoplasma gondii p548
Laurence Pelletier, Charlene A. Stern, Marc Pypaert, David Sheff, Huân M. Ngô, Nitin Roper, Cynthia Y. He, Ke Hu, Derek Toomre, Isabelle Coppens, David S. Roos, Keith A. Joiner and Graham Warren
doi:10.1038/nature00946
First paragraph | Full Text | PDF (515K) | Supplementary information
Two-step binding mechanism for T-cell receptor recognition of peptide–MHC p552
Lawren C. Wu, Delphine S. Tuot, Daniel S. Lyons, K. Christopher Garcia and Mark M. Davis
doi:10.1038/nature00920
First paragraph | Full Text | PDF (449K) | Supplementary information
APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit p556
Ralph Wäsch and Frederick R. Cross
doi:10.1038/nature00856
First paragraph | Full Text | PDF (1,332K) | Supplementary information
See also: News and Views by Morgan & Roberts
The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair p562
Karl-Peter Hopfner, Lisa Craig, Gabriel Moncalian, Robert A. Zinkel, Takehiko Usui, Barbara A. L. Owen, Annette Karcher, Brendan Henderson, Jean-Luc Bodmer, Cynthia T. McMurray, James P. Carney, John H. J. Petrini and John A. Tainer
doi:10.1038/nature00922
First paragraph | Full Text | PDF (441K) | Supplementary information
New on the Market
The voyage of discovery p567
Data mining, susceptibility testing, high-throughput screening for drugs.
doi:10.1038/418567a
