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Nature 418, 495-496 (1 August 2002) | doi:10.1038/418495a
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Cell cycle: Oscillation sensation
David O. Morgan1 & James M. Roberts2
Abstract
Various molecular actors play out the scene in which a cell exits mitosis — nuclear division — before entering the next cell cycle. One of them, the protein Clb2, steps back into the spotlight. Another, Clb5, bows out.
In 1982, while studying events in the early sea-urchin embryo, Tim Hunt1 found that one particular protein — which he called cyclin — is made and destroyed in each cell cycle. Murray and Kirschner2 later discovered that, in frog embryos, cyclins are the only proteins that need to be newly synthesized for the cell cycle to occur.
- David O. Morgan is in the Department of
Physiology, University of California at San Francisco, San
Francisco, California 94143-0444, USA.
e-mail: Email: dmorgan@cgl.ucsf.edu - James M. Roberts is at the Howard Hughes Medical
Institute, and the Division of Basic Sciences, Fred Hutchinson Cancer Research
Center, Seattle, Washington 98109-1024,
USA.
e-mail: Email: jroberts@fhcrc.org
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