Table of contents
Volume 418 Number 6896 pp3-463
Naturejobs
ProspectsWorking with the Framework p3
Paul Smaglik
doi:10.1038/nj6896-03a
movers
Medicine, Proteomics, Bioinformatics, Materials, Pharmaceuticals, Astronomy, Transitions p99
doi:10.1038/nj6896-99a
Opinion
Bigger isn't always better p353
The pharmaceutical industry's merger mania has done little to spur the innovation on which its future health will depend. Is it time to rethink the role of research within 'big pharma'?
doi:10.1038/418353a
News
Geneticist fears 'race-neutral' studies will fail ethnic groups p355
Peter Aldhous
doi:10.1038/418355a
Biotech firms spurn university site p355
Rex Dalton
doi:10.1038/418355b
Bioethics council demands tighter rules on gene patents p356
David Adam
doi:10.1038/418356a
Biologists angered by database access fee p357
Alison Abbott
doi:10.1038/418357a
Japan gives scientists political role p357
David Cyranoski
doi:10.1038/418357b
Lords blast red tape in animal experiments p358
Natasha McDowell
doi:10.1038/418358a
US labs bemoan lack of stem cells p358
Kendall Powell
doi:10.1038/418358b
Futurists predict body swaps for planet hops p359
Geoff Brumfiel
doi:10.1038/418359a
Imbalance a sticky issue among stamps of distinction p359
David Adam
doi:10.1038/418359b
news feature
Taxonomy: All living things, online p362
Can taxonomy shed its dusty image and reinvent itself as a vibrant discipline for the Internet age? Virginia Gewin talks to the pioneers who are trying to turn this vision into reality.
Virginia Gewin
doi:10.1038/418362a
Immunology: The virtue of tolerance p364
If specific immune responses could be toned down without completely suppressing immunity, it would provide a boon for the treatment of transplant rejection, autoimmune disease and allergy. Erika Check reports.
Erika Check
doi:10.1038/418364a
Correspondence
Taxonomy, at the click of a mouse p367
Informatics and taxonomy are working together to achieve more than either could alone.
Frank A. Bisby, Junko Shimura, Michael Ruggiero, James Edwards and Christoph Haeuser
doi:10.1038/418367a
Strong case for neutrons p367
B. Keimer
doi:10.1038/418367b
Book Reviews
The question of animal rights p369
Should cognitive ability determine which animals deserve legal rights?
Diana Reiss reviews Drawing the Line: Science and the Case for Animal Rights/Unlocking the Cage: Science and the Case for Animal Rights by Steven M. Wise
doi:10.1038/418369a
Replication at the speed of thought p370
Eörs Szathmáry reviews The Electric Meme: A New Theory of How We Think by Robert Aunger
doi:10.1038/418370a
Floral print p370
doi:10.1038/418370b
Running through the mind p371
Norman Myers reviews Lore of Running, 4th edition by Tim Noakes
doi:10.1038/418371a
Correction p371
doi:10.1038/418371b
concepts
Water management: Soft water paths p373
The soft path seeks to improve the overall productivity of water use and deliver water services matched to the needs of end users, rather than seeking sources of new supply.
Peter H. Gleick
doi:10.1038/418373a
News and Views
Chemistry: Much binding in the lab p375
Application of a concept drawn from two areas of macromolecular chemistry shows how artificial binding sites that resemble those found in globular proteins can be made.
Andrew D. Hamilton
doi:10.1038/418375a
Neurobiology: Full circle to cobbled brain p376
A biochemical link between certain congenital muscular dystrophies and the associated brain malformation known as cobblestone lissencephaly has been elusive. But it looks as if that link has been found.
M. Elizabeth Ross
doi:10.1038/418376a
Quantum physics: Spaced-out electrons p377
In a stream of photons, the particles tend to bunch together, but electrons in a beam do the opposite. At last, this quantum effect for free electrons — the Hanbury Brown–Twiss anticorrelation — has been seen experimentally.
John C. H. Spence
doi:10.1038/418377a
Medicine: Silencing viruses with RNA p379
Our cells have a built-in mechanism for 'silencing' genes, called RNA interference. This capability has now been exploited to protect cells in culture dishes from HIV-1 and poliovirus.
Gordon G. Carmichael
doi:10.1038/418379a
Biogeography: Springboards for springtails p381
Travel to overseas destinations is possible even for certain tiny land invertebrates. Although they cannot fly, the ocean is not an insuperable barrier because they can survive for longish periods in sea water.
Peter D. Moore
doi:10.1038/418381a
Sonoluminescence: Inside a micro-reactor p381
Gas bubbles in a liquid can convert sound energy into light. Detailed measurements of a single bubble show that, in fact, most of the sound energy goes into chemical reactions taking place inside this 'micro-reactor'.
Detlef Lohse
doi:10.1038/418381b
Genetics: Inherit the wheeze p383
A study of families containing asthma sufferers has led to the discovery of a gene that is associated with the disease. The finding brings the biological basis of asthma into sharper focus.
Jeffrey M. Drazen and Scott T. Weiss
doi:10.1038/418383a
100 and 50 years ago p384
doi:10.1038/418384a
Brief Communications
Antiferromagnets: Magnetic shape-memory effects in a crystal p385
A surprising new aspect is presented by an antiferromagnetic crystal structure.
A. N. Lavrov, Seiki Komiya and Yoichi Ando
doi:10.1038/418385a
First paragraph | Full Text | PDF (215K)
Pharmacology: Screening inhibitors of anthrax lethal factor p386
Fiorella Tonello, Michela Seveso, Oriano Marin, Michèle Mock and Cesare Montecucco
doi:10.1038/418386a
First paragraph | Full Text | PDF (69K) | Supplementary information
Article
Functional profiling of the Saccharomyces cerevisiae genome p387
Guri Giaever, Angela M. Chu, Li Ni, Carla Connelly, Linda Riles, Steeve Véronneau, Sally Dow, Ankuta Lucau-Danila, Keith Anderson, Bruno André, Adam P. Arkin, Anna Astromoff, Mohamed El Bakkoury, Rhonda Bangham, Rocio Benito, Sophie Brachat, Stefano Campanaro, Matt Curtiss, Karen Davis, Adam Deutschbauer, Karl-Dieter Entian, Patrick Flaherty, Francoise Foury, David J. Garfinkel, Mark Gerstein, Deanna Gotte, Ulrich Güldener, Johannes H. Hegemann, Svenja Hempel, Zelek Herman, Daniel F. Jaramillo, Diane E. Kelly, Steven L. Kelly, Peter Kötter, Darlene LaBonte, David C. Lamb, Ning Lan, Hong Liang, Hong Liao, Lucy Liu, Chuanyun Luo, Marc Lussier, Rong Mao, Patrice Menard, Siew Loon Ooi, Jose L. Revuelta, Christopher J. Roberts, Matthias Rose, Petra Ross-Macdonald, Bart Scherens, Greg Schimmack, Brenda Shafer, Daniel D. Shoemaker, Sharon Sookhai-Mahadeo, Reginald K. Storms, Jeffrey N. Strathern, Giorgio Valle, Marleen Voet, Guido Volckaert, Ching-yun Wang, Teresa R. Ward, Julie Wilhelmy, Elizabeth A. Winzeler, Yonghong Yang, Grace Yen, Elaine Youngman, Kexin Yu, Howard Bussey, Jef D. Boeke, Michael Snyder, Peter Philippsen, Ronald W. Davis and Mark Johnston
doi:10.1038/nature00935
Abstract | Full Text | PDF (317K) | Supplementary information
Letters to Nature
Observation of Hanbury Brown–Twiss anticorrelations for free electrons p392
Harald Kiesel, Andreas Renz and Franz Hasselbach
doi:10.1038/nature00911
First paragraph | Full Text | PDF (242K)
See also: News and Views by Spence
The energy efficiency of formation of photons, radicals and ions during single-bubble cavitation p394
Yuri T. Didenko and Kenneth S. Suslick
doi:10.1038/nature00895
First paragraph | Full Text | PDF (271K)
See also: News and Views by Lohse
Equilibrium lithium transport between nanocrystalline phases in intercalated TiO2 anatase p397
M. Wagemaker, A. P. M. Kentgens and F. M. Mulder
doi:10.1038/nature00901
First paragraph | Full Text | PDF (393K)
Synthetic hosts by monomolecular imprinting inside dendrimers p399
Steven C. Zimmerman, Michael S. Wendland, Neal A. Rakow, Ilya Zharov and Kenneth S. Suslick
doi:10.1038/nature00877
First paragraph | Full Text | PDF (344K) | Supplementary information
See also: News and Views by Hamilton
Tungsten isotope evidence from 
3.8-Gyr metamorphosed sediments for early meteorite bombardment of the Earth p403
Ronny Schoenberg, Balz S. Kamber, Kenneth D. Collerson and Stephen Moorbath
doi:10.1038/nature00923
First paragraph | Full Text | PDF (192K) | Supplementary information
A long-tailed, seed-eating bird from the Early Cretaceous of China p405
Zhonghe Zhou and Fucheng Zhang
doi:10.1038/nature00930
First paragraph | Full Text | PDF (679K) | Supplementary information
Mechanisms of long-distance dispersal of seeds by wind p409
Ran Nathan, Gabriel G. Katul, Henry S. Horn, Suvi M. Thomas, Ram Oren, Roni Avissar, Stephen W. Pacala and Simon A. Levin
doi:10.1038/nature00844
First paragraph | Full Text | PDF (314K)
A neural correlate of response bias in monkey caudate nucleus p413
Johan Lauwereyns, Katsumi Watanabe, Brian Coe and Okihide Hikosaka
doi:10.1038/nature00892
First paragraph | Full Text | PDF (338K)
Post-translational disruption of dystroglycan–ligand interactions in congenital muscular dystrophies p417
Daniel E. Michele, Rita Barresi, Motoi Kanagawa, Fumiaki Saito, Ronald D. Cohn, Jakob S. Satz, James Dollar, Ichizo Nishino, Richard I. Kelley, Hannu Somer, Volker Straub, Katherine D. Mathews, Steven A. Moore and Kevin P. Campbell
doi:10.1038/nature00837
First paragraph | Full Text | PDF (503K) | Supplementary information
See also: News and Views by Ross
Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy p422
Steven A. Moore, Fumiaki Saito, Jianguo Chen, Daniel E. Michele, Michael D. Henry, Albee Messing, Ronald D. Cohn, Susan E. Ross-Barta, Steve Westra, Roger A. Williamson, Toshinori Hoshi and Kevin P. Campbell
doi:10.1038/nature00838
First paragraph | Full Text | PDF (400K) | Supplementary information
See also: News and Views by Ross
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness p426
Paul Van Eerdewegh, Randall D. Little, Josée Dupuis, Richard G. Del Mastro, Kathy Falls, Jason Simon, Dana Torrey, Sunil Pandit, Joyce McKenny, Karen Braunschweiger, Alison Walsh, Ziying Liu, Brooke Hayward, Colleen Folz, Susan P. Manning, Alicia Bawa, Lisa Saracino, Michelle Thackston, Youssef Benchekroun, Neva Capparell, Mei Wang, Ron Adair, Yun Feng, JoAnn Dubois, Michael G. FitzGerald, Hui Huang, René Gibson, Kristina M. Allen, Alex Pedan, Melvyn R. Danzig, Shelby P. Umland, Robert W. Egan, Francis M. Cuss, Steuart Rorke, Joanne B. Clough, John W. Holloway, Stephen T. Holgate and Tim P. Keith
doi:10.1038/nature00878
First paragraph | Full Text | PDF (277K) | Supplementary information
See also: News and Views by Drazen & Weiss
Short interfering RNA confers intracellular antiviral immunity in human cells p430
Leonid Gitlin, Sveta Karelsky and Raul Andino
doi:10.1038/nature00873
First paragraph | Full Text | PDF (430K)
See also: News and Views by Carmichael
Modulation of HIV-1 replication by RNA interference p435
Jean-Marc Jacque, Karine Triques and Mario Stevenson
doi:10.1038/nature00896
First paragraph | Full Text | PDF (258K)
See also: News and Views by Carmichael
E3 ubiquitin ligase that recognizes sugar chains p438
Yukiko Yoshida, Tomoki Chiba, Fuminori Tokunaga, Hiroshi Kawasaki, Kazuhiro Iwai, Toshiaki Suzuki, Yukishige Ito, Koji Matsuoka, Minoru Yoshida, Keiji Tanaka and Tadashi Tai
doi:10.1038/nature00890
First paragraph | Full Text | PDF (430K) | Supplementary information
Distinct molecular mechanism for initiating TRAF6 signalling p443
Hong Ye, Joseph R. Arron, Betty Lamothe, Maurizio Cirilli, Takashi Kobayashi, Nirupama K. Shevde, Deena Segal, Oki K. Dzivenu, Masha Vologodskaia, Mijung Yim, Khoi Du, Sujay Singh, J. Wesley Pike, Bryant G. Darnay, Yongwon Choi and Hao Wu
doi:10.1038/nature00888
First paragraph | Full Text | PDF (480K) | Supplementary information
erratum: Regulation of Arabidopsis cryptochrome 2 by blue-light-dependent phosphorylation p447
Dror Shalitin, Hongyun Yang, Todd C. Mockler, Maskit Maymon, Hongwei Guo, Garry C. Whitelam and Chentao Lin
doi:10.1038/nature00951
New on the Market
A pot-pourri for the life sciences lab p448
Bunsen burners aren't what they used to be — is anything?
doi:10.1038/418448a
Technology Features
Screening for drug discovery: The leading question p453
Adam Smith
doi:10.1038/418453a
Automating the screening process p453
Adam Smith
doi:10.1038/418453b
Getting to know the family p455
Adam Smith
doi:10.1038/418455a
How small should you go? p457
Adam Smith
doi:10.1038/418457a
Fragmenting the problem p459
Adam Smith
doi:10.1038/418459a