The finding that a cellular compartment called the endoplasmic reticulum can merge with the cell's outer membrane is surprising. It would not have been predicted from our knowledge of cell organization.
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Swanson, J. The extraordinary phagosome. Nature 418, 286–287 (2002). https://doi.org/10.1038/418286a
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DOI: https://doi.org/10.1038/418286a