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Nature 418, 286-287 (18 July 2002) | doi:10.1038/418286a
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Assistant or Associate Professor of Neurobiology
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Cell biology: The extraordinary phagosome
Joel A. Swanson
Abstract
The finding that a cellular compartment called the endoplasmic reticulum can merge with the cell's outer membrane is surprising. It would not have been predicted from our knowledge of cell organization.
Within our cells are many membrane-bounded compartments, each of which communicates with only a subset of other such 'organelles' — generally when small vesicles bud off from one and merge with another. The efficiency with which cells use their organelles to carry out complex tasks has led to the belief that movement through the system of organelles occurs in strictly defined directions.
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