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Nature 418, 283-285 (18 July 2002) | doi:10.1038/418283a

Open Innovation Challenges

Population genetics: Malaria variorum

See associated Correspondence: Wu & Rogers, Nature 419, 15 (September 2002)

Andrew G. Clark

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A genetic study of the malaria parasite finds that this species is unexpectedly diverse. A second study shows multiple independent origins of mutations in one parasite gene that confer resistance to a widely used drug.

Understanding genetic variation in the malarial parasite, Plasmodium falciparum, is of major importance to public health, especially as we contemplate widespread programmes of vaccination. If a vaccine controls only part of the P. falciparum