Table of contents


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Naturejobs

Prospects

A chemical imbalance p3

Paul Smaglik

doi:10.1038/nj6894-03a


POSTDOCS

Gaining a lot from translation p5

Jan Schmollinger

doi:10.1038/nj6894-05a


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Opinion

After the gold-rush p111

Wall Street's technology-led boom distorted the priorities of research agencies. Its bust should remind scientists that public trust requires careful attention to ethics.

doi:10.1038/418111a


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News

Dubious data remain in print two years after misconduct inquiry p113

Alison Abbott and Johanna Schwarz

doi:10.1038/418113a


Europe gets tough on labelling genetically modified foodstuffs p114

Declan Butler

doi:10.1038/418114a


Botswana's AIDS laboratory squares up to HIV pandemic p114

Michael Cherry

doi:10.1038/418114b


AIDS meeting demands more than lip service p115

Declan Butler

doi:10.1038/418115a


Biology project left short of cash p115

David Cyranoski

doi:10.1038/418115b


Race is on to find alternative to animal tests p116

Sally Goodman

doi:10.1038/418116a


Japan lays out 55-point patent plan p116

David Cyranoski

doi:10.1038/418116b


Physicists plot mass production of neutrinos p117

David Adam

doi:10.1038/418117a


Public body appointed to clean up UK's nuclear legacy p117

David Adam

doi:10.1038/418117b


news in brief p118

doi:10.1038/418118a


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news feature

Misconduct in physics: Time to wise up? p120

With one of their brightest young stars facing allegations of data falsification, Geoff Brumfiel asks whether researchers in the physical sciences are ready to tackle the issue of misconduct.

Geoff Brumfiel

doi:10.1038/418120a


Gene regulation: The brave new world of RNA p122

Most of the RNA transcribed from your genome doesn't make protein. Carina Dennis talks to the revolutionaries who believe that it functions in gene-regulatory networks that underlie the complexity of higher organisms.

Carina Dennis

doi:10.1038/418122a


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Correspondence

Interoperability calls for an unusual mix of skills p125

Computer-science expertise will be a key ingredient of a successful 'bioinformatics nation'.

Fabien Campagne

doi:10.1038/418125a


Rebel army need not be a barrier to conservation p125

Craig Turner and Pete Raines

doi:10.1038/418125b


Jury out on Jefferson's alleged descendants p125

Steven T. Corneliussen

doi:10.1038/418125c


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Book Reviews

Networking comes of age p127

How an old concept has grown new wings.

Sidney Redner reviews Linked: The New Science of Networks by Albert-Lásló Barabási and Nexus: Small Worlds and the Groundbreaking Science of Networks/Small World: Uncovering Nature's Hidden Networks by Mark Buchanan

doi:10.1038/418127a


A right royal feud p128

Owen Gingerich reviews The Correspondence of John Flamsteed, First Astronomer Royal: Volume 3, 1703–1719 Compiled and edited by Eric G. Forbes, Lesley Murdin and Frances Willmoth

doi:10.1038/418128a


Evolution by design? p129

Brian Charlesworth reviews No Free Lunch: Why Specified Complexity Cannot Be Purchased without Intelligence by William A. Dembski

doi:10.1038/418129a


Rocky blues p129

doi:10.1038/418129b


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concepts

Complexity: The bigger picture p131

Tamas Vicsek

doi:10.1038/418131a


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News and Views

Palaeoanthropology: Hominid revelations from Chad p133

The story of human origins in Africa takes a twist with the description of a 6–7-million-year-old cranium from Chad. The discovery hints at the likely diversity of early hominids.

Bernard Wood

doi:10.1038/418133a


Planetary science: Out on the edge p135

The Kuiper Belt, beyond Neptune, is the third great domain of the Solar System, and home to the Pluto–Charon binary. What are the prospects for exploration of these distant worlds?

William B. McKinnon

doi:10.1038/418135a


Reproductive biology: Do the locomotion p137

Roger V. Short

doi:10.1038/418137a


Biodiversity: Bacterial game dynamics p138

Studies of three bacterial strains engaged in an interaction that mimics the game 'rock–paper–scissors' show the importance of localized interactions in maintaining biodiversity.

Martin A. Nowak and Karl Sigmund

doi:10.1038/418138a


Chemistry: Cleaning up catalysts p138

Magdalena Helmer

doi:10.1038/418138b


Apoptosis: Repulsive encounters p139

In multicellular organisms, cells are often required to die. They are then eaten by 'phagocytic' cells. But how do the phagocytes distinguish between dead and living prey? New work provides an unexpected answer.

Giovanna Chimini

doi:10.1038/418139a


Theoretical biology: Ants on a Turing trail p141

The behaviour of ants when dealing with their dead has parallels with biological pattern formation more generally, for instance as seen during development.

Peter Hammerstein and Olof Leimar

doi:10.1038/418141a


100 and 50 years ago p142

doi:10.1038/418142a


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Brief Communications

Herpetology: Snake circumvents constraints on prey size p143

Instead of swallowing a victim whole, crab-eating snakes tear off bite-sized pieces.

Bruce C. Jayne, Harold K. Voris and Peter K. L. Ng

doi:10.1038/418143a


Recombination: Multiply infected spleen cells in HIV patients p144

Andreas Jung, Reinhard Maier, Jean-Pierre Vartanian, Gennady Bocharov, Volker Jung, Ulrike Fischer, Eckart Meese, Simon Wain-Hobson and Andreas Meyerhans

doi:10.1038/418144a


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Articles

A new hominid from the Upper Miocene of Chad, Central Africa p145

Michel Brunet, Franck Guy, David Pilbeam, Hassane Taisso Mackaye, Andossa Likius, Djimdoumalbaye Ahounta, Alain Beauvilain, Cécile Blondel, Hervé Bocherens, Jean-Renaud Boisserie, Louis De Bonis, Yves Coppens, Jean Dejax, Christiane Denys, Philippe Duringer, Véra Eisenmann, Gongdibé Fanone, Pierre Fronty, Denis Geraads, Thomas Lehmann, Fabrice Lihoreau, Antoine Louchart, Adoum Mahamat, Gildas Merceron, Guy Mouchelin, Olga Otero, Pablo Pelaez Campomanes, Marcia Ponce De Leon, Jean-Claude Rage, Michel Sapanet, Mathieu Schuster, Jean Sudre, Pascal Tassy, Xavier Valentin, Patrick Vignaud, Laurent Viriot, Antoine Zazzo and Christoph Zollikofer

doi:10.1038/nature00879

See also: News and Views by Wood


Geology and palaeontology of the Upper Miocene Toros-Menalla hominid locality, Chad p152

Patrick Vignaud, Philippe Duringer, Hassane Taïsso Mackaye, Andossa Likius, Cécile Blondel, Jean-Renaud Boisserie, Louis de Bonis, Véra Eisenmann, Marie-Esther Etienne, Denis Geraads, Franck Guy, Thomas Lehmann, Fabrice Lihoreau, Nieves Lopez-Martinez, Cécile Mourer-Chauviré, Olga Otero, Jean-Claude Rage, Mathieu Schuster, Laurent Viriot, Antoine Zazzo and Michel Brunet

doi:10.1038/nature00880

See also: News and Views by Wood


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Letters to Nature

Possible in situ formation of meteoritic nanodiamonds in the early Solar System p157

Z. R. Dai, J. P. Bradley, D. J. Joswiak, D. E. Brownlee, H. G. M. Hill and M. J. Genge

doi:10.1038/nature00897


Phonon-enhanced light–matter interaction at the nanometre scale p159

R. Hillenbrand, T. Taubner and F. Keilmann

doi:10.1038/nature00899


Pressure-induced insulator–conductor transition in a photoconducting organic liquid-crystal film p162

Chong-yang Liu and Allen J. Bard

doi:10.1038/nature00875


Self-regeneration of a Pd-perovskite catalyst for automotive emissions control p164

Y. Nishihata, J. Mizuki, T. Akao, H. Tanaka, M. Uenishi, M. Kimura, T. Okamoto and N. Hamada

doi:10.1038/nature00893

See also: News and Views by Helmer


A satellite geodetic survey of large-scale deformation of volcanic centres in the central Andes p167

Matthew E. Pritchard and Mark Simons

doi:10.1038/nature00872


Local dispersal promotes biodiversity in a real-life game of rock–paper–scissors p171

Benjamin Kerr, Margaret A. Riley, Marcus W. Feldman and Brendan J. M. Bohannan

doi:10.1038/nature00823

See also: News and Views by Nowak & Sigmund


Exceptional sperm cooperation in the wood mouse p174

Harry Moore, Katerina Dvoráková, Nicholas Jenkins and William Breed

doi:10.1038/nature00832

See also: News and Views by Short


Transmitter-evoked local calcium release stabilizes developing dendrites p177

Christian Lohmann, Karen L. Myhr and Rachel O. L. Wong

doi:10.1038/nature00850


TRPV3 is a calcium-permeable temperature-sensitive cation channel p181

Haoxing Xu, I. Scott Ramsey, Suhas A. Kotecha, Magdalene M. Moran, Jayhong A. Chong, Deborah Lawson, Pei Ge, Jeremiah Lilly, Inmaculada Silos-Santiago, Yu Xie, Peter S. DiStefano, Rory Curtis and David E. Clapham

doi:10.1038/nature00882


TRPV3 is a temperature-sensitive vanilloid receptor-like protein p186

G. D. Smith, M. J. Gunthorpe, R. E. Kelsell, P. D. Hayes, P. Reilly, P. Facer, J. E. Wright, J. C. Jerman, J.-P. Walhin, L. Ooi, J. Egerton, K. J. Charles, D. Smart, A. D. Randall, P. Anand and J. B. Davis

doi:10.1038/nature00894


Release of chromatin protein HMGB1 by necrotic cells triggers inflammation p191

Paola Scaffidi, Tom Misteli and Marco E. Bianchi

doi:10.1038/nature00858


Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes p195

Tian H. Chi, Mimi Wan, Keji Zhao, Ichiro Taniuchi, Lei Chen, Dan R. Littman and Gerald R. Crabtree

doi:10.1038/nature00876


Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment p200

Simon Brown, Isabelle Heinisch, Ewan Ross, Kate Shaw, Chris D. Buckley and John Savill

doi:10.1038/nature00811

See also: News and Views by Chimini


Overexpression of beta-carotene hydroxylase enhances stress tolerance in Arabidopsis p203

P. A. Davison, C. N. Hunter and P. Horton

doi:10.1038/nature00861


NMR analysis of a 900K GroEL–GroES complex p207

Jocelyne Fiaux, Eric B. Bertelsen, Arthur L. Horwich and Kurt Wüthrich

doi:10.1038/nature00860


erratum: Optical pulsations from the anomalous X-ray pulsar 4U0142+61 p211

B. Kern and C. Martin

doi:10.1038/nature00881


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insight

foreword

RNA p213

Richard Turner

doi:10.1038/418213a


review article

The antiquity of RNA-based evolution p214

Gerald F. Joyce

doi:10.1038/418214a


The chemical repertoire of natural ribozymes p222

Jennifer A. Doudna and Thomas R. Cech

doi:10.1038/418222a


The involvement of RNA in ribosome function p229

Peter B. Moore and Thomas A. Steitz

doi:10.1038/418229a


Alternative pre-mRNA splicing and proteome expansion in metazoans p236

Tom Maniatis and Bosiljka Tasic

doi:10.1038/418236a


RNA interference p244

Gregory J. Hannon

doi:10.1038/418244a


Emerging clinical applications of RNA p252

Bruce A. Sullenger and Eli Gilboa

doi:10.1038/418252a


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