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Nature 418, 244-251 (11 July 2002) | doi:10.1038/418244a
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Professor / Reader
- LSTM
- Liverpool, United Kingdom
Section Chief of Molecular Diagnostics and Medical Director of Molecular Diagnotics Laboratory
- M. D. Anderson Cancer Center
- Houston, Texas, USA
review article RNA interference
Gregory J. Hannon
Abstract
A conserved biological response to double-stranded RNA, known variously as RNA interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. RNAi has been cultivated as a means to manipulate gene expression experimentally and to probe gene function on a whole-genome scale.
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