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Nature 418, 122-124 (11 July 2002) | doi:10.1038/418122a

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Gene regulation: The brave new world of RNA

Carina Dennis1

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Most of the RNA transcribed from your genome doesn't make protein. Carina Dennis talks to the revolutionaries who believe that it functions in gene-regulatory networks that underlie the complexity of higher organisms.

Biology's 'central dogma', laid down in the 1950s, states that genetic information flows from DNA to RNA to protein. Since then, numerous studies have shown that RNA does more than simply serve this intermediary function.